Synthesis and Antibacterial Activities of Yanglingmycin Analogues
| Autor: | Wenjia Dan, Jiwen Zhang, Zhi-Peng Yuan, Wenjun Wu, Longbo Li, Li-Hui Cui, Fangfang Tan |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Ralstonia solanacearum
biology Stereochemistry Chemistry Pseudomonas syringae Stereoisomerism Pathogenic bacteria Microbial Sensitivity Tests General Chemistry General Medicine medicine.disease_cause biology.organism_classification Anti-Bacterial Agents Mic values Drug Discovery medicine Yanglingmycin Enantiomer Antibacterial activity Spectral data Oxazoles |
| Zdroj: | Chemical and Pharmaceutical Bulletin. 63:33-37 |
| ISSN: | 1347-5223 0009-2363 |
| DOI: | 10.1248/cpb.c14-00578 |
| Popis: | The synthesis of Yanglingmycin and its enantiomer, along with eighteen Yanglingmycin analogues is reported. The structures were confirmed mainly by analyses of NMR spectral data. Antibacterial activity assays showed that Yanglingmycin and some of its analogues exhibited significant antibacterial activities against two important agricultural pathogenic bacteria, Ralstonia solanacearum and Pseudomonas syringae pv. actinidiae, with minimum inhibitory concentration (MIC) values ranging from 3.91 to 15.62 µg/mL. The antibacterial activities exhibited by Yanglingmycin and its analogues are promising, suggesting potential in the development of compounds for novel bactericides. |
| Databáze: | OpenAIRE |
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