BCL2 gene abnormalities define distinct clinical subsets of follicular lymphoma
| Autor: | Jo White, Neil M. Kernohan, David A. Levison, D Hamilton, John R. Goodlad, Paul J Batstone |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Male medicine.medical_specialty Pathology Histology Follicular lymphoma Chromosomal translocation Biology Polymerase Chain Reaction Translocation Genetic Pathology and Forensic Medicine hemic and lymphatic diseases medicine Humans Stage (cooking) Lymph node Lymphoma Follicular Survival analysis In Situ Hybridization Fluorescence Aged Aged 80 and over Chromosome Aberrations Chromosomes Human Pair 14 medicine.diagnostic_test Incidence (epidemiology) Anatomical pathology General Medicine Middle Aged medicine.disease Prognosis Survival Analysis Genes bcl-2 medicine.anatomical_structure Proto-Oncogene Proteins c-bcl-2 Female Neprilysin Chromosomes Human Pair 18 Fluorescence in situ hybridization |
| Zdroj: | Histopathology. 49(3) |
| ISSN: | 0309-0167 |
| Popis: | Aims: Follicular lymphoma (FL) arising primarily in the skin has recently been proposed as a distinct entity on the basis of a low incidence of t(14;18)(q32;q21) and bcl-2 expression, with a very high percentage of patients surviving more than 5 years. However, cases of t(14;18)(q32;q21)-positive primary cutaneous FL (PCFL) and examples of t(14;18)(q32;q21)-negative FL at nodal and other extranodal sites, are well documented. The aim of this study was to test the hypothesis that there is a subtype of FL lacking t(14;18)(q32;q21), which preferentially involves certain sites but is not restricted by anatomical location. Methods and results: A cohort of 47 stage 1 FL was stratified according to the presence or absence of t(14;18)(q32;q21) using conventional cytogenetics, polymerase chain reaction and interphase fluorescence in situ hybridization. Compared with t(14;18)(q32;q21)-positive cases, FL lacking the translocation were less likely to express CD10 or bcl-2 (P |
| Databáze: | OpenAIRE |
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