Nicotinamide N-Methyltransferase Is a Prognostic Biomarker and Correlated With Immune Infiltrates in Gastric Cancer
| Autor: | Guosheng Wang, Xiao-Fang Yu, Yihan Yao, Miaowei Wu, Weilei Hu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
lcsh:QH426-470 medicine.medical_treatment NNMT Regulator Nicotinamide N-methyltransferase 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Immune system Genetics Medicine Genetics (clinical) Original Research Nicotinamide treatment business.industry immune infiltration gastric cancer Immunotherapy lcsh:Genetics 030104 developmental biology chemistry 030220 oncology & carcinogenesis Cancer research Molecular Medicine Biomarker (medicine) biomarker business Toxicogenomics Felbinac medicine.drug |
| Zdroj: | Frontiers in Genetics, Vol 11 (2020) Frontiers in Genetics |
| ISSN: | 1664-8021 |
| DOI: | 10.3389/fgene.2020.580299/full |
| Popis: | Gastric cancer (GC) is the third most common cause of cancer-related death in the word. Immunotherapy is a promising treatment of cancer. However, it is unclear which GC subpopulation would benefit most from immunotherapy and it is necessary to develop effective biomarkers for predicting immunotherapy response. Nicotinamide N-methyltransferase (NNMT) is a metabolic regulator of cancer-associated fibroblast (CAF) differentiation and cancer progression. In this study, we explored the correlations of NNMT to tumor-infiltrating immune cells (TIICs) and immune marker sets in The Cancer Genome Atlas Stomach Adenocarcinoma STAD (TCGA-STAD). Subsequently, we screened the NNMT correlated genes and performed the enrichment analysis of these genes. We eventually predicted the 19 most potential small-molecule drugs using the connectivity map (CMap) and Comparative Toxicogenomics Database (CTD). Also, nadolol, tranexamic acid, felbinac and dapsone were considered the four most promising drugs for GC. In summary, NNMT can be used as a prognostic biomarker that reflect immune infiltration level and a novel therapeutic target in GC. |
| Databáze: | OpenAIRE |
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