T-cell lymphoblastic lymphoma with eosinophilia associated with subsequent myeloid malignancy
| Autor: | Medeiros Lj, Lynne V. Abruzzo, J. Whang-Peng, J. D. Cotelingam, Elaine S. Jaffe, V. Del Duca |
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| Rok vydání: | 1992 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Adolescent Biopsy Pathology and Forensic Medicine Immunophenotyping Cytogenetics immune system diseases Bone Marrow hemic and lymphatic diseases Antineoplastic Combined Chemotherapy Protocols Eosinophilia medicine Humans Child Myeloproliferative Disorders business.industry Histocytochemistry Lymphoblastic lymphoma Myeloid leukemia Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease Lymphoma Leukemia medicine.anatomical_structure Leukemia Myeloid Acute Disease Surgery Female Sarcoma Bone marrow Lymph Nodes Anatomy medicine.symptom business |
| Zdroj: | The American journal of surgical pathology. 16(3) |
| ISSN: | 0147-5185 |
| Popis: | Three patients with T-cell lymphoblastic lymphoma and peripheral blood eosinophilia are reported. At the time of diagnosis, all patients had lymphadenopathy, and one had a mediastinal mass. Lymph node biopsies revealed lymphoblastic lymphoma admixed with a variable number of mature eosinophils. Immunophenotypic studies demonstrated that each lymphoma had an immature T-cell immunophenotype. Bone marrow biopsies were hypercellular with myeloid hyperplasia and eosinophilia but were negative for lymphoma. All patients received multiagent chemotherapy; one patient achieved a complete remission, and two patients had partial remissions. All patients subsequently developed a myeloid malignancy. Two died of acute myeloid leukemia within 18 months of the diagnosis of lymphoblastic lymphoma. The third patient relapsed with a lymphoma that had histologic and immunophenotypic features of both T-cell lymphoblastic lymphoma and granulocytic sarcoma and also developed a poorly defined myeloproliferative disorder. These findings suggest that T-cell lymphoblastic lymphoma associated with eosinophilia may represent a distinct clinico-pathologic entity with a high risk of subsequent myeloid neoplasia. |
| Databáze: | OpenAIRE |
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