Reduced load-dependent default mode network deactivation across executive tasks in schizophrenia spectrum disorders

Autor: Ole A. Andreassen, Christian Thoresen, Jimmy Jensen, Ingrid Melle, Lars T. Westlye, C L Brandt, Torill Ueland, Tobias Kaufmann, Beathe Haatveit, Dag Alnæs
Rok vydání: 2016
Předmět:
Male
Functional magnetic resonance imaging
Neuropsychological Tests
Task-positive network
lcsh:RC346-429
Executive Function
0302 clinical medicine
Neural Pathways
Image Processing
Computer-Assisted
Cognitive impairment
Default mode network
Brain network
medicine.diagnostic_test
Across tasks
Regular Article
Cognition
Magnetic Resonance Imaging
Neurology
Schizophrenia
lcsh:R858-859.7
Female
Psychology
Cognitive psychology
Adult
Cognitive Neuroscience
Models
Neurological
Schizophrenia spectrum disorder
Independent component analysis
lcsh:Computer applications to medicine. Medical informatics
behavioral disciplines and activities
Young Adult
03 medical and health sciences
Reaction Time
medicine
Humans
Radiology
Nuclear Medicine and imaging
lcsh:Neurology. Diseases of the nervous system
Psychiatric Status Rating Scales
Analysis of Variance
Memory Disorders
medicine.disease
030227 psychiatry
Neurology (clinical)
Nerve Net
Cognition Disorders
human activities
030217 neurology & neurosurgery
Schizophrenia spectrum
Zdroj: NeuroImage: Clinical, Vol 12, Iss C, Pp 389-396 (2016)
NeuroImage : Clinical
ISSN: 2213-1582
Popis: Background Schizophrenia is associated with cognitive impairment and brain network dysconnectivity. Recent efforts have explored brain circuits underlying cognitive dysfunction in schizophrenia and documented altered activation of large-scale brain networks, including the task-positive network (TPN) and the task-negative default mode network (DMN) in response to cognitive demands. However, to what extent TPN and DMN dysfunction reflect overlapping mechanisms and are dependent on cognitive state remain to be determined. Methods In the current study, we investigated the recruitment of TPN and DMN using independent component analysis in patients with schizophrenia spectrum disorders (n = 29) and healthy controls (n = 21) during two different executive tasks probing planning/problem-solving and spatial working memory. Results We found reduced load-dependent DMN deactivation across tasks in patients compared to controls. Furthermore, we observed only moderate associations between the TPN and DMN activation across groups, implying that the two networks reflect partly independent mechanisms. Additionally, whereas TPN activation was associated with task performance in both tasks, no such associations were found for DMN. Conclusion These results support a general load-dependent DMN dysfunction in schizophrenia spectrum disorder across two demanding executive tasks that is not merely an epiphenomenon of cognitive dysfunction.
Highlights • SZ patients have reduced load-dependent DMN deactivation compared to controls. • TPN activation is associated with task performance, whereas DMN deactivation is not. • There are only moderate associations between the TPN and DMN activation.
Databáze: OpenAIRE
Externí odkaz: