Association Study of Single Nucleotide Polymorphisms on Chromosome 19q13 With Abdominal Aortic Aneurysm
| Autor: | Bart P. Boll, Jean-Paul P. M. de Vries, Annette F. Baas, Diederick E. Grobbee, Ruben van 't Slot, Marc R.H.M. van Sambeek, Jelena Medic, Bob H. Geelkerken, Cisca Wijmenga, Jan D. Blankensteijn, Ynte M. Ruigrok |
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| Přispěvatelé: | Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), Surgery, ICaR - Ischemia and repair |
| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
Population Single-nucleotide polymorphism association study DISEASE FAMILIES abdominal aortic aneurysm 9P21 Genetic linkage single nucleotide polymorphism Genetic variation Genotype medicine LINKAGE linkage analysis Allele education Allele frequency METAANALYSIS POPULATION Genetics education.field_of_study business.industry Haplotype Surgery PREVALENCE GENOME SEQUENCE VARIANT cardiovascular system Cardiology and Cardiovascular Medicine business 19q13 |
| Zdroj: | Baas, A F, Medic, J, van't Slot, R, Vries, J P P, van Sambeek, M R H M, Geelkerken, B H, Boll, B P, Grobbee, D E, Wijmenga, C, Ruigrok, Y M & Blankensteijn, J D 2010, ' Association Study of Single Nucleotide Polymorphisms on Chromosome 19q13 With Abdominal Aortic Aneurysm ', Angiology, vol. 61, no. 3, pp. 243-247 . https://doi.org/10.1177/0003319709354752 Angiology, 61(3), 243-247. SAGE Publications Inc. |
| ISSN: | 0003-3197 |
| DOI: | 10.1177/0003319709354752 |
| Popis: | Background: Abdominal aortic aneurysm (AAA) is a complex disorder in which environmental and genetic factors play a role in pathogenesis. Linkage to 2 adjacent loci on 19q13 in familiar AAA was previously demonstrated. We studied whether genetic variation within these regions predisposes to AAA. Methods: Common genetic variants in the described regions on 19q13 were analyzed using tag single nucleotide polymorphisms (SNPs) in a Dutch case-control population. Single nucleotide polymorphism genotyping was performed in a 2-stage approach. Results: In stage 1, 615 SNPs were genotyped in 376 AAA patients and 648 controls. In stage 2, 8 SNPs of stage 1 with a P value < .015 were genotyped in a second independent cohort of 360 cases and 376 controls. No differences in allele frequencies were observed. Conclusion: Our findings suggest that there are no common AAA predisposing SNPs within the 19q13 loci. Hence, the genetic basis of familiar and sporadic AAA may differ. |
| Databáze: | OpenAIRE |
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