Increased adipose tissue lipolysis after a 2-week high-fat diet in sedentary overweight/obese men
| Autor: | Kimberly Heidal, Kristen E. Boyle, Robert C. Hickner, Myung Dong Choi, Harold R. Howe, Ray M. Kraus |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Glycerol Male medicine.medical_specialty Microdialysis Adolescent Endocrinology Diabetes and Metabolism Lipolysis Subcutaneous Fat Adipose tissue Overweight Biology Article chemistry.chemical_compound Young Adult Endocrinology Internal medicine medicine Humans Obesity Triglycerides Triglyceride Cholesterol Cholesterol HDL medicine.disease Dietary Fats chemistry medicine.symptom Sedentary Behavior Body mass index |
| Zdroj: | Metabolism: clinical and experimental. 60(7) |
| ISSN: | 1532-8600 |
| Popis: | The purpose of this study was to determine if a high-fat diet would result in a higher lipolytic rate in subcutaneous adipose tissue than a lower-fat diet in sedentary nonlean men. Six participants (healthy males; 18-40 years old; body mass index, 25-37 kg/m 2 ) underwent 2 weeks on a high-fat or well-balanced diet of similar energy content (approximately 6695 kJ) in randomized order with a 10-day washout period between diets. Subcutaneous abdominal adipose tissue lipolysis was determined over the course of a day using microdialysis after both 2-week diet sessions. Average interstitial glycerol concentrations (index of lipolysis) as determined using microdialysis were higher after the high-fat diet (210.8 ± 27.9 μ mol/L) than after a well-balanced diet (175.6 ± 23.3 μ mol/L; P = .026). There was no difference in adipose tissue microvascular blood flow as determined using the microdialysis ethanol technique. These results demonstrate that healthy nonlean men who diet on the high-fat plan have a higher lipolytic rate in subcutaneous abdominal adipose tissue than when they diet on a well-balanced diet plan. This higher rate of lipolysis may result in a higher rate of fat mass loss on the high-fat diet; however, it remains to be determined if this higher lipolytic rate in men on the high-fat diet results in a more rapid net loss of triglyceride from the abdominal adipose depots, or if the higher lipolytic rate is counteracted by an increased rate of lipid storage. |
| Databáze: | OpenAIRE |
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