Epigenetic age associates with psychosocial stress and resilience in children of Latinx immigrants
| Autor: | Amy L. Non, Alexandra M. Binder, Elizabeth S Clausing |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Epigenomics Cancer Research Adolescent media_common.quotation_subject Immigration Ethnic group Emigrants and Immigrants Biology Epigenesis Genetic 03 medical and health sciences 0302 clinical medicine Genetics Humans Epigenetics Child media_common Stressor DNA Methylation 030104 developmental biology DNA methylation Psychological resilience Psychosocial 030217 neurology & neurosurgery Stress Psychological Social status Clinical psychology Genome-Wide Association Study |
| Zdroj: | Epigenomics. 13(21) |
| ISSN: | 1750-192X |
| Popis: | Aim: To investigate associations of psychosocial stressors and resilience factors with DNA methylation age in the saliva of Latinx children of immigrants before and after the 2016 presidential election (2015–2018). Materials & methods: We compared psychosocial exposures with four distinct measures of epigenetic age assessed in the saliva of children (6–13 years, n = 71 pre-election; n = 35 post-election). Exploratory genome-wide analyses were also conducted. Results: We found distinct associations across epigenetic clocks and time points; for example, greater maternal social status pre-election and fear of parent deportation post-election both associated with decreased Hannum age (p ≤ 0.01). Conclusion: Although limited in size, our unique study design provides novel hypotheses regarding how the social environment may influence epigenetic aging and genome-wide methylation, potentially contributing to racial/ethnic health inequalities. |
| Databáze: | OpenAIRE |
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