Non-contact photoacoustic tomography and ultrasonography for tissue imaging
| Autor: | Guy Rousseau, Jean-Pierre Monchalin, Alain Blouin |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2011 |
| Předmět: |
ocis:(120.0280) Remote sensing and sensors
Materials science ocis:(110.5120) Photoacoustic imaging business.industry Stray light ocis:(280.3375) Laser induced ultrasonics Confocal Ultrasound Photoacoustic Imaging and Spectroscopy Laser Atomic and Molecular Physics and Optics law.invention Interferometry ocis:(170.1470) Blood or tissue constituent monitoring Optics law Medical imaging ocis:(110.7170) Ultrasound Ultrasonic sensor Ultrasonography ocis:(170.3880) Medical and biological imaging business Biotechnology |
| Zdroj: | Biomedical Optics Express |
| ISSN: | 2156-7085 |
| Popis: | The detection of ultrasound in photoacoustic tomography (PAT) and ultrasonography (US) usually relies on ultrasonic transducers in contact with the biological tissue. This is a major drawback for important potential applications such as surgery and small animal imaging. Here we report the use of remote optical detection, as used in industrial laser-ultrasonics, to detect ultrasound in biological tissues. This strategy enables non-contact implementation of PAT and US without exceeding laser exposure safety limits. The method uses suitably shaped laser pulses and a confocal Fabry-Perot interferometer in differential configuration to reach quantum-limited sensitivity. Endogenous and exogenous inclusions exhibiting optical and acoustic contrasts were detected ex vivo in chicken breast and calf brain specimens. Inclusions down to 0.5 mm in size were detected at depths well exceeding 1 cm. The method could significantly expand the scope of applications of PAT and US in biomedical imaging. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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