Zinc oxide-curcumin nanocomposite loaded collagen membrane as an effective material against methicillin-resistant coagulase-negative Staphylococci
| Autor: | Jyothis Mathew, E. K. Radhakrishnan, Sheela Sugathan, K. R. Soumya, S. Snigdha |
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| Rok vydání: | 2017 |
| Předmět: |
Materials science
Nanocomposite medicine.drug_class Antibiotics chemistry.chemical_element 02 engineering and technology Zinc Environmental Science (miscellaneous) 010402 general chemistry 021001 nanoscience & nanotechnology Antimicrobial 01 natural sciences Agricultural and Biological Sciences (miscellaneous) In vitro 0104 chemical sciences Microbiology chemistry.chemical_compound Minimum inhibitory concentration chemistry Curcumin medicine Original Article Coagulase 0210 nano-technology Biotechnology |
| Zdroj: | 3 Biotech. 7(4) |
| ISSN: | 2190-572X |
| Popis: | Zinc oxide nanoparticles and curcumin are excellent antimicrobial agents. They have the potential to be used as alternative to antibiotics in wound infection management. In this study, ZnO–curcumin nanocomposite was synthesized and characterized. Physical adsorption of the nanocomposite onto collagen skin wound dressing was conducted and structural investigation was carried out by SEM. Antimicrobial assay, minimum inhibitory concentration (MIC), and viability assays of different concentrations of nanocomposite loaded collagen membrane were conducted against clinically isolated methicillin-resistant coagulase-negative Staphylococci (MRCoNS), such as S. epidermidis, S. hemolyticus, and S. saprophyticus. The nanocomposite showed excellent anti-CoNS activity on time kill assay with the MIC value of 195 µg/mL against S. epidermidis, S. hemolyticus and 390 µg/mL against S. saprophyticus. The nanocomposite loaded collagen membrane also showed excellent in vitro antistaphylococcal activity. This study may lead to the development of antibiotic alternate strategies to control and limit the MRCoNS in wound-related infections. |
| Databáze: | OpenAIRE |
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