Thrombolytic therapy in the treatment of acute sub-massive pulmonary embolism: a prospective observational study
| Autor: | Babu Reddy, BC Srinivas, Navin Agrawal, Soumya Patra, Cholenhally Nanjappa Manjunath, Chamrajnagara M. Nagesh, Krishnappa Shankarappa Ravindranath |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty law.invention Young Adult Randomized controlled trial Fibrinolytic Agents law Risk Factors Internal medicine medicine.artery Medicine Humans Thrombolytic Therapy Prospective Studies Young adult Prospective cohort study Aged business.industry Hematology General Medicine Middle Aged medicine.disease Confidence interval Pulmonary embolism Blood pressure Treatment Outcome Pulmonary artery Cardiology Observational study Female business Pulmonary Embolism |
| Zdroj: | Blood coagulationfibrinolysis : an international journal in haemostasis and thrombosis. 25(2) |
| ISSN: | 1473-5733 |
| Popis: | The use of thrombolytic therapy in haemodynamically stable patients with sub-massive pulmonary embolism is still controversial. We conducted this study to observe the safety and efficacy of thrombolytic therapy in acute pulmonary embolism patients with normal blood pressure in a tertiary cardiac centre. In this study, 130 patients with sub-massive pulmonary embolism who had right-ventricular dysfunction were included and treated with thrombolytic therapy. Forty-one percent of patients in our study were within 40 years of age. Eighty-three percent of patients had clinical improvement. Both right-ventricular dysfunction and pulmonary artery systolic pressure were improved significantly following thrombolytic therapy from baseline (49 vs. 28 mmHg; P = 0.01; 95% confidence interval -13 to -56). Only 9% patients had died and two patients had intra-cerebral haemorrhage during this study. Thrombolytic therapy may be helpful in improving clinical course following sub-massive acute pulmonary embolism, especially for those who had low risk of bleeding. Further randomized study with large sample size is needed for final conclusion. |
| Databáze: | OpenAIRE |
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