Bilirubin Concentration Correlates With Positive Symptoms in Patients With Schizophrenia
| Autor: | Georg Kemmler, Monika Edlinger, W. Wolfgang Fleischhacker, Maria A. Rettenbacher, Christian G. Widschwendter, Susanne Baumgartner, Alex Hofer |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Bilirubin medicine.medical_treatment Statistics as Topic medicine.disease_cause Gastroenterology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine Humans In patient Longitudinal Studies Antipsychotic Psychiatric Status Rating Scales Positive and Negative Syndrome Scale Middle Aged medicine.disease Pathophysiology 030227 psychiatry Oxidative Stress Psychiatry and Mental health chemistry Schizophrenia Female Schizophrenic Psychology Psychology 030217 neurology & neurosurgery Oxidative stress Antipsychotic Agents Follow-Up Studies Psychopathology Clinical psychology |
| Zdroj: | The Journal of Clinical Psychiatry. 77:512-516 |
| ISSN: | 0160-6689 |
| DOI: | 10.4088/jcp.14m09642 |
| Popis: | OBJECTIVE Besides its toxic effects, bilirubin has been demonstrated to have antioxidant properties to counteract oxidative stress, which has been suggested to play a role in the pathophysiology of schizophrenia. METHODS This study investigated the potential association between changes in psychopathology measured by the Lindenmayer model of the Positive and Negative Syndrome Scale (PANSS) and changes in total plasma bilirubin concentrations. Data of patients with schizophrenia (ICD-10) starting monotherapy with a new-generation antipsychotic were analyzed at baseline (N = 52) and 2 (n = 40), 4 (n = 46), and 12 weeks (n = 30) after the initiation of treatment. Data were collected between December 1997 and October 2007 and analyzed retrospectively. RESULTS The PANSS total score decreased significantly from baseline to weeks 2, 4, and 12 of treatment (all P values ≤ .001). Total plasma bilirubin concentration also dropped significantly from baseline to week 2 (P = .015) and decreased further until week 4 (P = .013); no significant decrease was observed between baseline and week 12. Spearman rank correlation revealed a significant association of bilirubin concentration with the PANSS positive (r = 0.371, P = .007) and excitement (r = 0.322, P = .020) components at baseline. No further correlations were found. From baseline to weeks 2, 4, and 12, changes in the PANSS positive component correlated significantly with changes in plasma bilirubin concentration (all P values < .05), whereas correlations between changes in the remaining PANSS components and bilirubin were less consistent. CONCLUSIONS Assuming that positive symptoms are associated with the subjective experience of psychological distress, our findings indirectly expand the evidence on potential antioxidant properties of bilirubin in patients with schizophrenia. |
| Databáze: | OpenAIRE |
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