Vital Role of Monoamine Oxidases and Cholinesterases in Central Nervous System Drug Research: A Sharp Dissection of the Pathophysiology
| Autor: | Erkan Aksoz, Begüm Evranos Aksöz |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Parkinson's disease
Monoamine oxidase Central nervous system Rivastigmine Pharmacology Central nervous system disease Structure-Activity Relationship Central Nervous System Diseases Drug Discovery medicine Cholinesterases Humans Donepezil Cognitive decline Enzyme Inhibitors Monoamine Oxidase Cholinesterase biology business.industry Galantamine Organic Chemistry General Medicine medicine.disease Combined Modality Therapy Computer Science Applications Monoamine neurotransmitter medicine.anatomical_structure Drug Design biology.protein Tacrine business Acetylcholine medicine.drug Central Nervous System Agents |
| Zdroj: | Combinatorial chemistryhigh throughput screening. 23(9) |
| ISSN: | 1875-5402 |
| Popis: | Background: Monoamine oxidase and cholinesterase enzymes are very critical enzymes that regulate the level of neurotransmitters such as acetylcholine and monoamines. Monoamine neurotransmitters and acetylcholine play a very important role in many physiological events. An increase or decrease in the amount of these neurotransmitters is observed in a wide range of central nervous system pathologies. Balancing the amount of these neurotransmitters is important in improving the progression of these diseases. Inhibitors of monoamine oxidase and cholinesterase enzymes are important in symptomatic therapy and delaying progression of a group of central nervous system disease manifested with memory loss, cognitive decline and psychiatric disturbances like depression. Objective: In this article, the relationship between central nervous system diseases and the vital role of the enzymes, monoamine oxidase and cholinesterase, is discussed on the pathophysiologic basis, focusing on drug research. Conclusion: Monoamine oxidase and cholinesterase enzymes are still a good target for the development of novel drug active substances with optimized pharmacokinetic and pharmacodynamic properties, which can maximize the benefits of current therapy modalities. |
| Databáze: | OpenAIRE |
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