Aggravation of functional mitral regurgitation on left ventricle stiffness in type 2 diabetes mellitus patients evaluated by CMR tissue tracking
| Autor: | Li Jiang, Meng-ting Shen, Wei-feng Yan, Shan Huang, Yuan Li, Yi Zhang, Zhi-gang Yang, Ke Shi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Diabetic Cardiomyopathies Endocrinology Diabetes and Metabolism Diastole Regurgitation (circulation) 030204 cardiovascular system & hematology Ventricular Function Left Strain Ventricular Dysfunction Left 03 medical and health sciences 0302 clinical medicine Magnetic resonance imaging Predictive Value of Tests Diabetes mellitus Internal medicine Type 2 diabetes mellitus Humans Medicine Diseases of the circulatory (Cardiovascular) system 030212 general & internal medicine Heart valve Aged Original Investigation Angiology medicine.diagnostic_test business.industry Mitral Valve Insufficiency Middle Aged Left ventricle Prognosis medicine.disease Preload medicine.anatomical_structure Diabetes Mellitus Type 2 Ventricle Functional mitral regurgitation RC666-701 Disease Progression Cardiology Mitral Valve Female Cardiology and Cardiovascular Medicine business |
| Zdroj: | Cardiovascular Diabetology, Vol 20, Iss 1, Pp 1-10 (2021) Cardiovascular Diabetology |
| ISSN: | 1475-2840 |
| Popis: | Background Functional mitral regurgitation (FMR) is one of the most common heart valve diseases in diabetes and may increase left ventricular (LV) preload and aggravate myocardial stiffness. This study aimed to investigate the aggravation of FMR on the deterioration of LV strain in type 2 diabetes mellitus (T2DM) patients and explore the independent indicators of LV peak strain (PS). Materials and methods In total, 157 T2DM patients (59 patients with and 98 without FMR) and 52 age- and sex-matched healthy control volunteers were included and underwent cardiac magnetic resonance examination. T2DM with FMR patients were divided into T2DM patients with mild (n = 21), moderate (n = 19) and severe (n = 19) regurgitation. LV function and global strain parameters were compared among groups. Multivariate analysis was used to identify the independent indicators of LV PS. Results The T2DM with FMR had lower LV strain parameters in radial, circumferential and longitudinal direction than both the normal and the T2DM without FMR (all P P Conclusion FMR may aggravate the deterioration of LV stiffness in T2DM patients, resulting in decline of LV strain and function. The regurgitation degree and months with diabetes were independently correlated with LV global PS in T2DM with FMR. |
| Databáze: | OpenAIRE |
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