Genetic properties of the MAGIC maize population: a new platform for high definition QTL mapping in Zea mays
| Autor: | Htay Htay Aung, Elisabetta Frascaroli, Dirk Inzé, Daniel M. Gatti, G. Pea, Gabriele Magris, Federica Cattonaro, Mario Enrico Pè, Joke Baute, Frederik Coppens, Michele Morgante, Hilde Nelissen, Aye L. Hlaing, Gary A. Churchill, Matteo Dell’Acqua |
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| Přispěvatelé: | Dell'Acqua, Matteo, Gatti, Daniel M, Pea, Giorgio, Cattonaro, Federica, Coppens, Frederik, Magris, Gabriele, Hlaing, Aye L, Aung, Htay H, Nelissen, Hilde, Baute, Joke, Frascaroli, Elisabetta, Churchill, Gary A, Inzé, Dirk, Morgante, Michele, Pè, Mario Enrico |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
0106 biological sciences
QTL mapping Candidate gene Heterosis Population Quantitative Trait Loci DNA-SEQUENCING DATA COLLABORATIVE CROSS INTER-CROSS POPULATION Quantitative trait locus Biology maize 01 natural sciences LONG NONCODING RNAS Zea mays 03 medical and health sciences Family-based QTL mapping Genetic variation FLOWERING-TIME Plant breeding GENOME-WIDE ASSOCIATION education Zea mays mapping population QTL sequencing transcriptomics 030304 developmental biology 2. Zero hunger Genetics 0303 health sciences education.field_of_study Genetic diversity QUANTITATIVE TRAIT LOCI RECOMBINANT INBRED LINES Research COMPLEX TRAITS multiparental population fungi technology industry and agriculture Biology and Life Sciences food and beverages Chromosome Mapping Genetic Variation Research Highlight Plant Breeding Evolutionary biology ARABIDOPSIS-THALIANA Transcriptome Genome Plant 010606 plant biology & botany multiparental population QTL mapping maize |
| Zdroj: | Genome Biology GENOME BIOLOGY |
| ISSN: | 1465-6906 |
| Popis: | Background Maize (Zea mays) is a globally produced crop with broad genetic and phenotypic variation. New tools that improve our understanding of the genetic basis of quantitative traits are needed to guide predictive crop breeding. We have produced the first balanced multi-parental population in maize, a tool that provides high diversity and dense recombination events to allow routine quantitative trait loci (QTL) mapping in maize. Results We produced 1,636 MAGIC maize recombinant inbred lines derived from eight genetically diverse founder lines. The characterization of 529 MAGIC maize lines shows that the population is a balanced, evenly differentiated mosaic of the eight founders, with mapping power and resolution strengthened by high minor allele frequencies and a fast decay of linkage disequilibrium. We show how MAGIC maize may find strong candidate genes by incorporating genome sequencing and transcriptomics data. We discuss three QTL for grain yield and three for flowering time, reporting candidate genes. Power simulations show that subsets of MAGIC maize might achieve high-power and high-definition QTL mapping. Conclusions We demonstrate MAGIC maize’s value in identifying the genetic bases of complex traits of agronomic relevance. The design of MAGIC maize allows the accumulation of sequencing and transcriptomics layers to guide the identification of candidate genes for a number of maize traits at different developmental stages. The characterization of the full MAGIC maize population will lead to higher power and definition in QTL mapping, and lay the basis for improved understanding of maize phenotypes, heterosis included. MAGIC maize is available to researchers. Electronic supplementary material The online version of this article (doi:10.1186/s13059-015-0716-z) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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