| Autor: |
Chimeze, Valery Wilfried Nguemdjo, Bankoglu, Ezgi Eyluel, Zühlke, Sebastian, Fannang, Véronique Simone, Eckelmann, Dennis, Shirri, Jovita Chi, Djuidje, Ernestine Nicaise, Djama, Céline Mbazoa, Stopper, Helga, Wandji, Jean |
| Rok vydání: |
2021 |
| DOI: |
10.6084/m9.figshare.14610084.v1 |
| Popis: |
A phytochemical investigation of the liana of Artabotrys thomsonii led to the isolation of a new oxoberberine alkaloid, 2,10-dihydroxy-3,9-dimethoxy-8-oxo-protoberberine (7), along with six known compounds. Their chemical structures were elucidated by 1 D and 2 D NMR spectroscopic methods and HRESI-MSn data analysis. Compounds 4 and 7 were selected for further in vitro investigations. In accordance with expectations from their chemical structures, compounds 7 and 4 showed a clear antioxidant activity in a cell-free assay, with compound 7 being 7-fold more active than 4. Cytotoxicity, cytostatic and genotoxic effects only occurred at high micromolar concentrations of 50 µM or more. Compound 7 was slightly less effective than compound 4. A low micromolar concentration of 10 µM did not cause any damaging cellular effects but showed potential for a protection against the micronucleus-inducing effect of reactive oxygen species hydrogen peroxide, although not to a significant extent. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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