Spontaneous regression of multiple pulmonary metastases accompanied by normalization of serum immune markers following cytoreductive nephrectomy in a patient with clear‐cell renal cell carcinoma
| Autor: | Kohei Takei, Toyonori Tsuzuki, Takao Kamai, Natsumi Ishikawa, Toshiki Kijima, Hirotaka Fuchizawa, Issei Suzuki, Akihito Okazaki, Philipp Schiller, Kazumasa Sakamoto |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Oncology
medicine.medical_specialty renal cell carcinoma Urology medicine.medical_treatment Case Report Inflammation Case Reports lcsh:RC870-923 Immune system Immunity Renal cell carcinoma spontaneous neoplasm regression Internal medicine medicine nephrectomy business.industry medicine.disease lcsh:Diseases of the genitourinary system. Urology Primary tumor immunity Regression Nephrectomy Clear cell renal cell carcinoma inflammation medicine.symptom business |
| Zdroj: | IJU Case Reports, Vol 4, Iss 2, Pp 95-99 (2021) IJU Case Reports |
| Popis: | Introduction The spontaneous regression of metastases, which mostly occurs after surgical resection of the primary tumor, has been described in various malignancies, including renal cell carcinoma. The involvement of the host immune system is currently postulated as the underlying mechanism. Case presentation We present a case of metastatic clear‐cell renal cell carcinoma that achieved complete spontaneous regression of multiple pulmonary metastases preceded by normalization of serum immune markers after cytoreductive nephrectomy. The patient remained disease free for 3 years without any systemic therapy, suggesting that postoperative normalization of serum immune markers may indicate recovery of the host immune system, which prevents tumor recurrence. Conclusion Monitoring of serum immune markers may be useful to identify patients with recovered immune function and, therefore, may not require systemic therapy. Similarly, the case suggests a potential role of cytoreductive nephrectomy in the contemporary management of metastatic renal cell carcinoma. |
| Databáze: | OpenAIRE |
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