Congenital anomalies in children with pre‐ or perinatally acquired cerebral palsy: an international data linkage study

Autor: Eve Blair, Guro L. Andersen, Sarah McIntyre, Kate Himmelmann, Catherine S. Gibson, Shona Goldsmith, Hayley Smithers-Sheedy, Nadia Badawi, Ester Garne
Rok vydání: 2020
Předmět:
Male
Pediatrics
medicine.medical_specialty
Registo Nacional de Anomalias Congénitas
Information Storage and Retrieval
Comorbidity
Total population
Mutually exclusive events
Major Congenital Anomaly
Congenital Abnormalities
Cerebral palsy
European Surveillance of Congenital Anomalies
Registos Epidemiológicos
03 medical and health sciences
0302 clinical medicine
Developmental Neuroscience
EUROCAT
030225 pediatrics
Prevalence
medicine
PNVPC
Humans
Registries
Child
Children
Data Linkage
Causal pathways
Programa Nacional de Vigilância da Paralisia Cerebral
Portugal
business.industry
Cerebral Palsy
RENAC
Australia
Congenital Anomalies
Estados de Saúde e de Doença
medicine.disease
Paralisia Cerebral
Europe
Child
Preschool
Pediatrics
Perinatology and Child Health
Female
Neurology (clinical)
business
Anomalias Congénitas
030217 neurology & neurosurgery
Zdroj: The Comprehensive CA-CP Study Group 2021, ' Congenital anomalies in children with pre-or perinatally acquired cerebral palsy : an international data linkage study ', Developmental Medicine and Child Neurology, vol. 63, no. 4, pp. 413-420 . https://doi.org/10.1111/dmcn.14602
ISSN: 1469-8749
0012-1622
DOI: 10.1111/dmcn.14602
Popis: Members of the Comprehensive CA-CP study group: Paula Braz and Daniel Virella, Portugal. Departamento de Epidemiologia do INSA Aim: To describe the frequency and types of major congenital anomalies present in children with pre- or perinatally acquired cerebral palsy (CP), and compare clinical outcomes for children with and without anomalies. Method: This multi-centre total population collaborative study between Surveillance of Cerebral Palsy in Europe, Australian Cerebral Palsy Register, and European Surveillance of Congenital Anomalies (EUROCAT) involved six European and three Australian regions. Data were linked between each region's CP and congenital anomaly register for children born between 1991 and 2009, and then pooled. Children were classified into mutually exclusive categories based on type of anomaly. Proportions of children with congenital anomalies were calculated, and clinical outcomes compared between children with and without anomalies. Results: Of 8201 children with CP, 22.8% (95% confidence interval [CI] 21.9, 23.8) had a major congenital anomaly. Isolated cerebral anomalies were most common (45.2%), with a further 8.6% having both cerebral and non-cerebral anomalies. Cardiac anomalies only were described in 10.5% of children and anomalies associated with syndromes were also reported: genetic (8.0%), chromosomal (5.7%), and teratogenic (3.0%). Clinical outcomes were more severe for children with CP and congenital anomalies, particularly cerebral anomalies. Interpretation: This large, international study reports major congenital anomalies in nearly one-quarter of children with pre- or perinatally acquired CP. Future research must focus on aetiological pathways to CP that include specific patterns of congenital anomalies. What this paper adds: Congenital anomalies were reported in 23% of children with pre- or perinatally acquired cerebral palsy. A higher proportion of children born at or near term had anomalies. The most common type of anomalies were isolated cerebral anomalies. Clinical outcomes were more severe for children with congenital anomalies (particularly cerebral). Cerebral Palsy Alliance Research Foundation. Grant Numbers: PG1215, PG2816, Salary support (SG, SM, HSS, NB) info:eu-repo/semantics/publishedVersion
Databáze: OpenAIRE
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