Clinical outcome following radiotherapy and planned neck dissection in N+ head and neck cancer patients
| Autor: | Alexander Ahlberg, Magnus Lagerlund, Freddi Lewin, Signe Friesland, Jan Lundgren |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.medical_treatment Kaplan-Meier Estimate Metastasis medicine Humans External beam radiotherapy Aged Retrospective Studies Aged 80 and over Sweden business.industry Head and neck cancer Cancer Neck dissection General Medicine Middle Aged Prognosis medicine.disease Surgery Radiation therapy Dissection Otorhinolaryngology Head and Neck Neoplasms Carcinoma Squamous Cell Neck Dissection Female Histopathology business Neck |
| Zdroj: | Acta Oto-Laryngologica. 128:1354-1360 |
| ISSN: | 1651-2251 0001-6489 |
| Popis: | This study confirms earlier findings that patients with viable tumour cells in the neck after external beam radiotherapy (EBRT) have a poor prognosis. The study also indicates that neck dissection (ND) does not change the prognosis for patients with a complete clinical response in the neck. At the moment our guidelines concerning this matter are being reviewed.The protocol at our institution stipulates a planned ND in patients with metastasis in the neck after EBRT regardless of the response in the neck. As the necessity for a planned ND has not been clarified we wanted to evaluate our results.Patients diagnosed from 1998 to 2002 with metastasis in the neck who received EBRT were evaluated for histopathological findings and clinical outcome.A total of 156 patients were included. Overall survival was 62% and disease-specific survival was 76%. There was a complete response (CR) in the neck in 63 patients (40%); among these 15 had viable tumour cells in the neck. In patients not achieving CR, 40% (37/93) had viable tumour cells left in the neck. Patients with viable tumour cells in the neck after EBRT had disease-specific survival of 48% compared with 90% among patients without viable tumour cells. |
| Databáze: | OpenAIRE |
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