Three Novel Bicyclic 3,8-Secotaxane Diterpenoids from the Needles of the Chinese Yew, Taxus chinensis var. mairei
| Autor: | Takeyoshi Sugiyama, Qing-Wen Shi, Hiromasa Kiyota, Takayuki Oritani |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Pharmacology
biology Bicyclic molecule Stereochemistry Organic Chemistry Taxuspine Taxus chinensis var. mairei Pharmaceutical Science Pharmacognosy biology.organism_classification Terpenoid Analytical Chemistry chemistry.chemical_compound Complementary and alternative medicine chemistry Taxus Drug Discovery Molecular Medicine Spectral analysis Diterpene |
| Zdroj: | Journal of Natural Products. 61:1437-1440 |
| ISSN: | 1520-6025 0163-3864 |
| DOI: | 10.1021/np980213q |
| Popis: | Three novel (1-3) and five known bicyclic 3,8-secotaxane diterpenoids were isolated from the needles of the Chinese yew, Taxus chinensis var. mairei. The structures of the new compounds were established, respectively, as (3E,7E)-2alpha,10beta, 13alpha-triacetoxy-5alpha,20-dihydroxy-3,8-secotaxa-3,7, 11-trien-9-one (1), (3E,7E)-2alpha,10beta-diacetoxy-5alpha,13alpha, 20-trihydroxy-3,8-secotaxa-3,7,11-trien-9-one (2), and (3E,8E)-7beta, 9,10beta,13alpha,20-pentaacetoxy-3,8-secotaxa-3,8,11-triene-2alpha, 5alpha-diol (2-deacetyltaxachitriene A) (3), on the basis of spectral analysis. The other five bicyclic taxane diterpenoids were determined as canadensene, 5-deacetyltaxachitriene B, taxachitriene B, taxuspine U, and taxuspine X by comparison of their physical properties and spectral data with those previously reported. |
| Databáze: | OpenAIRE |
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