| Zdroj: |
Pietersz, R N I, Reesink, H W, Panzer, S, Oknaian, S, Kuperman, S, Gabriel, C, Rapaille, A, Lambermont, M, Deneys, V, Sondag, D, Ramírez-Arcos, S, Goldman, M, Delage, G, Bernier, F, Germain, M, Vuk, T, Georgsen, J, Morel, P, Naegelen, C, Bardiaux, L, Cazenave, J-P, Dreier, J, Vollmer, T, Knabbe, C, Seifried, E, Hourfar, K, Lin, C K, Spreafico, M, Raffaele, L, Berzuini, A, Prati, D, Satake, M, de Korte, D, van der Meer, P F, Kerkhoffs, J L, Blanco, L, Kjeldsen-Kragh, J, Svard-Nilsson, A-M, McDonald, C P, Symonds, I, Moule, R, Brailsford, S, Yomtovian, R & Jacobs, M R 2014, ' Bacterial contamination in platelet concentrates ', Vox Sanguinis, vol. 106, no. 3, pp. 256-283 . https://doi.org/10.1111/vox.12098 |
| Popis: |
R. N. I. Pietersz, H. W. Reesink, S. Panzer, S. Oknaian, S. Kuperman, C. Gabriel, A. Rapaille, M. Lambermont, V. Deneys,D. Sondag, S. Ramirez-Arcos, M. Goldman, G. Delage, F. Bernier, M. Germain, T. Vuk, J. Georgsen, P. Morel, C. Naegelen,L. Bardiaux, J.-P. Cazenave, J. Dreier, T. Vollmer, C. Knabbe, E. Seifried, K. Hourfar, C. K. Lin, M. Spreafico, L. Raffaele,A. Berzuini, D. Prati, M. Satake, D. de Korte, P. F. van der Meer, J. L. Kerkhoffs, L. Blanco, J. Kjeldsen-Kragh,A.-M. Svard-Nilsson, C. P. McDonald, I. Symonds, R. Moule, S. Brailsford, R. Yomtovian & M. R. JacobsSeptic reactions after transfusion, particularly of plateletconcentrates, still occur and belong to the most serioustransfusion reactions. From a previous InternationalForum [1] on the subject, it could be concluded that inpart of the countries that participated in the forum, plate-let concentrates (PCs) were tested for bacterial contamina-tion and that culture-based methods, particularly theBacT/Alert system, were used.In recent years, several rapid bacterial detection meth-ods, such as surrogate measurements of the pH or glu-cose, the detection of bacteria with a scan system orPCR tests that detect bacterial RNA, have been devel-oped. These tests can either be performed immediatelyprior to transfusion of the PC or at a variety of testmoments at which culture and release tests are com-bined.Pathogen inactivation (PI) methods also affect bacterialcontamination of PCs. In 2007 [1], in some countries, theIntercept method of PI of PCs was implemented insteadof bacterial screening.It seemed of interest to evaluate the present state ofthe art of this subject. In order to obtain the desiredinformation, the following questions were sent to expertsin the field.Question 1: How long do you store PC and is there adifference between whole-blood-derived PC and apheresisPC? Which method of preparation do you use for whole-blood-derived PC? Are PCs leuco-reduced?Question 2: Do you use a culture method to detect bac-terial contamination of PC? If so |
