15‐Hydroperoxy‐PGE2: Intermediate in Mammalian and Algal Prostaglandin Biosynthesis
| Autor: | Georg Pohnert, Hans Jagusch, Markus Werner, Oliver Werz |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
Gracilaria vermiculophylla 010405 organic chemistry Chemistry Metabolite Inflammation General Chemistry General Medicine 010402 general chemistry 01 natural sciences Catalysis 0104 chemical sciences chemistry.chemical_compound Prostaglandin biosynthesis Enzyme Biochemistry Biosynthesis Alternative complement pathway medicine lipids (amino acids peptides and proteins) medicine.symptom |
| Zdroj: | Angewandte Chemie International Edition |
| ISSN: | 1521-3757 0044-8249 |
| DOI: | 10.1002/ange.201910461 |
| Popis: | Arachidonic-acid-derived prostaglandins (PGs), specifically PGE2 , play a central role in inflammation and numerous immunological reactions. The enzymes of PGE2 biosynthesis are important pharmacological targets for anti-inflammatory drugs. Besides mammals, certain edible marine algae possess a comprehensive repertoire of bioactive arachidonic-acid-derived oxylipins including PGs that may account for food poisoning. Described here is the analysis of PGE2 biosynthesis in the red macroalga Gracilaria vermiculophylla that led to the identification of 15-hydroperoxy-PGE2 , a novel precursor of PGE2 and 15-keto-PGE2 . Interestingly, this novel precursor is also produced in human macrophages where it represents a key metabolite in an alternative biosynthetic PGE2 pathway in addition to the well-established arachidonic acid-PGG2 -PGH2 -PGE2 route. This alternative pathway of mammalian PGE2 biosynthesis may open novel opportunities to intervene with inflammation-related diseases. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |