Autofluorescence-guided surgery for the treatment of medication-related osteonecrosis of the jaw (MRONJ): a retrospective single-center study
| Autor: | Teresa Franziska Brunner, Sven Otto, Riham Fliefel, Selgai Haidari, Matthias Troeltzsch, Oliver Ristow, Michael Ehrenfeld, Mohamed Mosleh, Christoph Pautke, Suad Aljohani, Eva Maria Schnödt |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Single Center Pathology and Forensic Medicine Resection 03 medical and health sciences 0302 clinical medicine Primary outcome medicine Humans Radiology Nuclear Medicine and imaging Dentistry (miscellaneous) Stage (cooking) Retrospective Studies Maxillofacial surgeons Bone Density Conservation Agents business.industry Treatment options Retrospective cohort study 030206 dentistry medicine.disease Surgery 030220 oncology & carcinogenesis Bisphosphonate-Associated Osteonecrosis of the Jaw Oral Surgery Osteonecrosis of the jaw business |
| Zdroj: | Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 131:519-526 |
| ISSN: | 2212-4403 |
| Popis: | Objective Medication-related osteonecrosis of the jaw (MRONJ) has become a serious concern for patients under antiresorptive treatment, especially in the oncological setting. Different approaches have been described in the management of MRONJ, including innovative autofluorescence-guided surgery. However, until now, there has been a lack of data regarding the outcome. In this study, we evaluated the efficacy of minimally invasive autofluorescence-guided resection in MRONJ. Study Design Seventy-five patients with 82 lesions were included in this retrospective, single-center study. All included patients were diagnosed with MRONJ according to the American Association of Oral and Maxillofacial Surgeons guidelines and underwent autofluorescence-guided surgery with a minimum follow-up of 3 months. The primary outcome was complete integrity of the mucosa and absence of bone exposure. Results The MRONJ stages were stage 0 (3.7%), stage 1 (3.7%), stage 2 (75.6%), and stage 3 (17%). Overall, complete mucosal healing of all lesions after the first surgery was 81.7% (67 of 82), whereas it was 90.2% (74 of 82) after revision surgery. Conclusions The study showed that autofluorescence-guided surgery is a safe and successful treatment option that can be considered for all stages of MRONJ. |
| Databáze: | OpenAIRE |
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