Platelet–derived growth factor (PDGF) and receptor (PDGFR) expression in human meningiomas: correlations with clinicopathological features and cytogenetic analysis
| Autor: | J. F. Pellissier, N. Bianco, A. M. Vagner–Capodano, D. Figarella–Branger, D. Gambarelli, H. Zattara–Cannoni, N. Graziani, F. Grisoli, B. Devictor, P. Bouillot |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Monosomy Histology Platelet-derived growth factor Proto-Oncogene Mas Pathology and Forensic Medicine Meningioma chemistry.chemical_compound Isomerism Physiology (medical) Meningeal Neoplasms otorhinolaryngologic diseases medicine Humans Receptors Platelet-Derived Growth Factor Receptor neoplasms Aged Aged 80 and over Platelet-Derived Growth Factor PDGFB Staining and Labeling biology Antibodies Monoclonal Middle Aged medicine.disease nervous system diseases Neurology chemistry Karyotyping Immunologic Techniques biology.protein Female Neurology (clinical) Chromosome 22 Platelet-derived growth factor receptor Immunostaining |
| Zdroj: | Neuropathology and Applied Neurobiology. 20:439-447 |
| ISSN: | 1365-2990 0305-1846 |
| Popis: | PDGFs and their receptors expression were examined in a series of 46 meningiomas by using specific monoclonal antibodies. The immunostaining was quantified by an image analyser and the results correlated with clinical and morphological data (histological type and grade). In addition, since the PDGFB chain is encoded by the c-sis proto-oncogene localized on chromosome 22 and because monosomy 22 has been frequently reported in meningiomas, PDGFs and PDGFRs expression have been correlated with cytogenetic analysis performed in 29 cases. The results demonstrate PDGF A and PDGF B expression in most meningioma specimens and co-expression of these growth factors in numerous cells. PDGF A and B immunoreactivity was related to histological grade. PDGFR beta expression was strong in almost all meningiomas whereas PDGFR alpha was low. PDGFR alpha expression was related to tumour location and grade and PDGFR beta to histological subtype only. The cytogenetic analysis was not related to PDGFB chain expression. Taken together these data further confirm PDGF and PDGFR expression in human meningioma; PDGF may exist as an heterodimer (AB) as well as its receptor. The lack of correlation between cytogenetic analysis and PDGF values, the low level of PDGFB in recurrent meningiomas suggests that it is unlikely that the c-sis proto-oncogene plays an important role in the genesis of meningiomas. |
| Databáze: | OpenAIRE |
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