Platelet proinflammatory activity in clinically stable patients with CF starts in early childhood
| Autor: | Ralf Grossmann, Corinne Koenig, Helge Hebestreit, Ulrich Walter, Alexander Sturm |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Adult
Blood Platelets Pulmonary and Respiratory Medicine Adolescent Cystic Fibrosis medicine.medical_treatment CD40 Ligand Integrin Inflammation Platelet Glycoprotein GPIIb-IIIa Complex Exocytosis Proinflammatory cytokine Young Adult Downregulation and upregulation Leukocytes medicine Humans Platelet Pediatrics Perinatology and Child Health Platelet activation Child biology business.industry Age Factors Platelet Activation P-Selectin Cytokine Case-Control Studies Child Preschool Pediatrics Perinatology and Child Health Immunology biology.protein Cytokines medicine.symptom business |
| Zdroj: | Journal of Cystic Fibrosis. 9:179-186 |
| ISSN: | 1569-1993 |
| DOI: | 10.1016/j.jcf.2009.12.004 |
| Popis: | Background Early onset chronic inflammation is present in CF. Platelets may contribute to inflammation by cytokine release and interaction with leukocytes. Methods Parameters of platelet proinflammatory function (soluble CD62P, soluble CD40L, the percentage of platelet–leukocyte aggregates, platelet CD62P) and platelet procoagulatory function (PAC-1-binding to activated integrin α IIb β 3 and expression of integrin α IIb β 3 =CD41a) were measured in patients and controls. Results Levels of sCD62P, sCD40L were increased in CF irrespective of age and activity of inflammation. The number of platelet–leukocyte aggregates was elevated in older CF patients. PAC-1-binding to platelets decreased with growing activity of inflammation. Exocytosis of CD41a upon platelet activation was reduced. Conclusion In CF, platelet proinflammatory activity is increased at very young age already and might promote inflammation and tissue damage. On the other hand, platelets seem to downregulate the activation of their most important integrin (α IIb β 3 ) for clot formation. |
| Databáze: | OpenAIRE |
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