Holmium-166-DTPA as a liquid source for endovascular brachytherapy
| Autor: | Sang Moo Choi, Kyung Bae Park, Young-Don Hong, Sun-Ju Choi, Young-Mi Kim, Beom-Su Jang |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Biodistribution Metabolic Clearance Rate animal diseases Radiation Brachytherapy Brachytherapy Holmium-166-DTPA chemistry.chemical_element Sensitivity and Specificity Whole-Body Counting law.invention Holmium Restenosis Pharmacokinetics law medicine Animals Tissue Distribution Radiology Nuclear Medicine and imaging Vascular Diseases Gamma camera Radioisotopes organic chemicals Radiochemistry Reproducibility of Results Pentetic Acid respiratory system medicine.disease Rats Endovascular brachytherapy Solutions chemistry Isotope Labeling Injections Intravenous cardiovascular system Molecular Medicine Rabbits Radiology Radiopharmaceuticals circulatory and respiratory physiology |
| Zdroj: | Nuclear Medicine and Biology. 29:833-839 |
| ISSN: | 0969-8051 |
| Popis: | Liquid radiation sources with β emitters have advantages of accurate positioning and uniform dose distribution to the vessel walls to prevent the restenosis of coronary artery. As a liquid radiation source, 166 Ho-DTPA was prepared and evaluated its in-vivo pharmacokinetic behavior through animal studies. 166 Ho-DTPA was prepared by simple mixing the Holmium with DTPA at room temperature. The radiolabelling yield was 100% when the DTPA/Holmium molar ratio was >2. Radiolabelling of 166 Ho-DTPA was not dependent on the pH range of 1.7–7.5. High radiochemical stability (>98%) was maintained over a period of 6 hours even with a radioactivity (∼11.1 GBq/12 mg of DTPA) stored at room temperature. Biodistribution of 166 Ho-DTPA in rats and gamma camera images in rabbits showed that 166 Ho-DTPA was quickly excreted via the urinary system. The average of T max and T 1/2 of 166 Ho-DTPA in the kidneys of rabbits were 3.71 ± 1.18 min and 9.15 ± 3.15 min. 166 Ho-DTPA is a potential liquid radiation source for radiation brachytherapy to prevent the restenosis of the coronary artery using a liquid-filled balloon. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect