Isorhamnetin 3-O-neohesperidoside promotes the resorption of crown-covered bone during tooth eruption by osteoclastogenesis
| Autor: | Wenzhi Shang, Yi Mao, Jinze Zhen, Fuju Zheng, Xijiao Yu, Shanyong Zhang, Yanmei Du |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Flavonols lcsh:Medicine Osteoclasts Bone Marrow Cells Bone and Bones Article Bone resorption Tooth Eruption Mice 03 medical and health sciences chemistry.chemical_compound Bone remodelling 0302 clinical medicine Osteogenesis In vivo Internal medicine Developmental biology medicine Cathepsin K Animals Bone Resorption lcsh:Science Isorhamnetin Tartrate-resistant acid phosphatase Multidisciplinary biology Macrophages lcsh:R RANK Ligand Cell Differentiation 030206 dentistry Drug regulation Resorption Mice Inbred C57BL 030104 developmental biology Endocrinology medicine.anatomical_structure Gene Expression Regulation chemistry RANKL biology.protein lcsh:Q Quercetin Bone marrow Signal Transduction |
| Zdroj: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020) |
| ISSN: | 2045-2322 |
| DOI: | 10.1038/s41598-020-62107-7 |
| Popis: | Delayed resorption of crown-covered bone is a critical cause of delayed tooth eruption. Traditional herbal medicines may be good auxiliary treatments to promote the resorption of crown-covered bone. This study was carried out to analyse the effect of isorhamnetin 3-O-neohesperidoside on receptor activator of nuclear factor-kB ligand (RANKL)-induced osteoclastogenesis in vitro and resorption of the crown-covered bone of the lower first molars in mice in vivo. Isorhamnetin 3-O-neohesperidoside promoted osteoclastogenesis and the bone resorption of mouse bone marrow macrophages (BMMs) and upregulated mRNA expression of the osteoclast-specific genes cathepsin K (CTSK), vacuolar-type H + -ATPase d2(V-ATPase d2), tartrate resistant acid phosphatase (TRAP) and nuclear factor of activated T-cells cytoplasmic 1 (NFATc1). NFATc1, p38 and AKT signalling was obviously activated by isorhamnetin 3-O-neohesperidoside in osteoclastogenesis. Isorhamnetin 3-O-neohesperidoside aggravated resorption of crown-covered bone in vivo. In brief, isorhamnetin 3-O-neohesperidoside might be a candidate adjuvant therapy for delayed intraosseous eruption. |
| Databáze: | OpenAIRE |
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