Melanoma subtypes demonstrate distinct PD-L1 expression profiles
| Autor: | Robert A. Anders, Meg R. Gerstenblith, Genevieve J. Kaunitz, Evan J. Lipson, Charles G. Eberhart, Sneha Berry, Valliammai Muthappan, Cheryl L. Thompson, Janis M. Taube, Jessica Esandrio, James T. Handa, Alexander H. Fischer, Stefan Kraft, Aleksandra Ogurtsova, Haiying Xu, Kord Honda, Jonathan D. Cuda, Mohammed Lilo, Tricia R. Cottrell |
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| Rok vydání: | 2017 |
| Předmět: |
Uveal Neoplasms
0301 basic medicine Pathology medicine.medical_specialty Skin Neoplasms Lymphocyte Uveal Neoplasm Lentigo maligna Biology Cell morphology B7-H1 Antigen Article Pathology and Forensic Medicine Cohort Studies 03 medical and health sciences 0302 clinical medicine medicine Humans Melanoma Molecular Biology Skin Gene Expression Profiling Cell Biology medicine.disease Gene expression profiling 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Cutaneous melanoma Immunohistochemistry |
| Zdroj: | Laboratory Investigation. 97:1063-1071 |
| ISSN: | 0023-6837 |
| Popis: | PD-L1 expression in the tumor immune microenvironment is recognized as both a prognostic and predictive biomarker in patients with cutaneous melanoma, a finding closely related to its adaptive (IFN-γ-mediated) mechanism of expression. Approximately 35% of cutaneous melanomas express PD-L1, however, the expression patterns, levels, and prevalence in rarer melanoma subtypes are not well described. We performed immunohistochemistry for PD-L1 and CD8 on 200 formalin-fixed paraffin-embedded specimens from patients with acral (n = 16), mucosal (n = 36), uveal (n = 103), and chronic sun-damaged (CSD) (n = 45) melanomas (24 lentigo maligna, 13 ‘mixed’ desmoplastic, and 8 ‘pure’ desmoplastic melanomas). CD8+ tumor-infiltrating lymphocyte (TIL) densities were characterized as mild, moderate, or severe, and their geographic association with PD-L1 expression was evaluated. Discrete lymphoid aggregates, the presence of a spindle cell morphology, and the relationship of these features with PD-L1 expression were assessed. PD-L1 expression was observed in 31% of acral melanomas, 44% of mucosal melanomas, 10% of uveal melanomas, and 62% of CSD melanomas (P |
| Databáze: | OpenAIRE |
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