Impact of body mass index on progression of primary immunoglobulin a nephropathy
Autor: | Aswani Srinivas Mareddy, Rajeevalochana Parthasarathy, Uday Venkat Mateti, Srikanth Prasad, Sindhu Kaza, Shankar Prasad Nagaraju, Srinivas Kosuru, Karan Saraf, Sindhura Lakshmi Koulmane Laxminarayana, Srinivas Shenoy, Dharshan Rangaswamy, Ravindra Prabhu Attur, Vasudeva Guddattu |
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Rok vydání: | 2018 |
Předmět: |
Adult
Male Nephrology medicine.medical_specialty Time Factors lcsh:Medicine India Renal function 030204 cardiovascular system & hematology Kidney urologic and male genital diseases Gastroenterology Body Mass Index Young Adult 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine 0502 economics and business Humans Medicine Obesity Risk factor Retrospective Studies Proteinuria business.industry lcsh:R 05 social sciences Glomerulonephritis IGA Retrospective cohort study General Medicine Prognosis medicine.disease Cohort Disease Progression Kidney Failure Chronic Female 050211 marketing medicine.symptom business Body mass index Glomerular Filtration Rate Kidney disease |
Zdroj: | Saudi Journal of Kidney Diseases and Transplantation, Vol 29, Iss 2, Pp 318-325 (2018) |
ISSN: | 1319-2442 |
DOI: | 10.4103/1319-2442.229261 |
Popis: | The role of obesity in the progression of primary glomerular diseases is controversial. A few studies report overweight/obesity as a risk factor for disease progression in immunoglobulin A nephropathy (IgAN), and the real impact of it still remains unclear. The aim of this study was to elucidate the effect of body mass index (BMI) on disease progression and proteinuria in patients with IgAN in Indian population. A cohort of biopsy-proven primary IgAN patients diagnosed between March 2010 and February 2015 who had a follow-up for a minimum of 12 months were included in the study. We defined two groups of patients according to the BMI value at diagnosis: non-obese group (Group N) with BMI 23 Kg/m2 as per Asia-Pacific task force criteria. Baseline characteristics were compared between the groups. The estimated glomerular filtration rate (eGFR) and urine protein-creatinine ratio (UPCR) were followed up at entry time, 6 months, 12 months, and at the end of follow-up. Outcomes studied were change in eGFR, proteinuria, and progression to end-stage renal disease. Statistical analysis was done using the Statistical Package for the Social Sciences version 15.0. Of 51 patients, 25 (49%) had BMI 23 kg/m2 (Group O) (P = 0.01). The baseline clinical, histopathological, and treatment characteristics of both the groups were comparable. The BMI at the time of diagnosis did not have any significant effect on eGFR (P = 0.41) or proteinuria (P = 0.99) at presentation. At the end of follow-up, both the groups had a similar reduction of proteinuria (UPCR) (P = 0.46) and eGFR (P = 0.20). Two patients in each group have reached chronic kidney disease Stage 5. In the present study, BMI at presentation did not have any impact on eGFR or proteinuria, either at diagnosis or at follow-up. It needs further large multicenter randomized control studies to see the effect of BMI on progression of IgAN. |
Databáze: | OpenAIRE |
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