Expression and function of histamine H4 receptor in mouse splenic dendritic cells
| Autor: | Valéria László, Tünde Simon, Gy. Apponyi, András Falus, Éva Rajnavölgyi, Ivett Jelinek |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_treatment
Immunology Antigen presentation Blotting Western Cell Separation Receptors G-Protein-Coupled Histamine Agonists Histamine receptor chemistry.chemical_compound Mice Immune system Antigen medicine Animals Histamine H4 receptor Elméleti orvostudományok RNA Messenger Receptors Histamine H4 Pharmacology Antigen Presentation Mice Inbred BALB C Follicular dendritic cells Chemistry Orvostudományok Dendritic Cells Flow Cytometry Cell biology CD11c Antigen Cytokine Receptors Histamine Electrophoresis Polyacrylamide Gel Histamine Spleen |
| Zdroj: | Inflammation research : official journal of the European Histamine Research Society ... [et al.]. 59 |
| ISSN: | 1420-908X |
| Popis: | Dendritic cells (DC) are the master regulators of the immune system. DCs act as ‘‘sentinels’’ and they are the most potent antigen-presenting cells specialized for capture, transport, processing and presentation of antigens [1]. During these activities numerous factors may influence their functions. Histamine is one of these mediators released from neighboring mast cells, basophils, and even from the DCs themselves [2]. Histamine exerts its physiological functions through four different G protein-linked receptors: H1R, H2R, H3R, and the recently discovered H4R [3]. In contrast to other histamine receptors, H4R expression shows tissue specificity, it is mainly found in immune cells, e.g. mast cells, eosinophils, T cells, and DCs. Very recently, it has also been detected in the mouse central nervous system [4]. H4R expression has been investigated mainly on the mRNA level, and it has been also described in murine bone marrow-derived DCs. The involvement of H4R in the regulation of DC chemotaxis and cytokine production has been newly published [5]. We have studied the expression of H4R protein in mouse splenic DCs and its possible role in a major DC function, namely antigen presentation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink