Effects of Low Doses of Essential Oil on the Antioxidant State of the Erythrocytes, Liver, and the Brains of Mice
| Autor: | I. B. Medvedeva, A. I. Kozachenko, Elena B. Burlakova, Tamara A. Misharina, L. D. Fatkullina, A. N. Goloshchapov, L. G. Nagler, E. S. Alinkina |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Cell Membrane Permeability Antioxidant Membrane Fluidity Syzygium medicine.medical_treatment Ginger Extract Ginger Biology Pharmacology Antioxidants law.invention Lipid peroxidation Mice chemistry.chemical_compound law In vivo Origanum Oils Volatile medicine Animals Plant Oils Essential oil Glutathione Transferase chemistry.chemical_classification Glutathione Peroxidase Mice Inbred BALB C Superoxide Dismutase Glutathione peroxidase Erythrocyte Membrane Brain General Medicine medicine.disease Hemolysis Liver chemistry Biochemistry Lipid Peroxidation Fisetin |
| Zdroj: | Прикладная биохимия и микробиология. 50:101-107 |
| ISSN: | 0555-1099 |
| DOI: | 10.7868/s0555109914010097 |
| Popis: | We studied the effects of essential oil from oregano and clove and a mixture of lemon essential oil and a ginger extract on the antioxidant state of organs in intact and three experimental groups of Bulb mice. We found that the essential oil was an efficient in vivo bioantioxidant when mice were treated with it for 6 months even at very low doses, such as 300 ng/day. All essential oil studied inhibited lipid peroxidation (LPO) in the membranes of erythrocytes that resulted in increased membrane resistance to spontaneous hemolysis, decreased membrane microviscosity, maintenance of their structural integrity, and functional activity. The essential oil substantially decreased the LPO intensity in the liver and the brains of mice and increased the resistance of liver and brain lipids to oxidation and the activity of antioxidant enzymes in the liver. The most expressed bioantioxidant effect on erythrocytes was observed after clove oil treatment, whereas on the liver and brain, after treatment with a mixture of lemon essential oil and a ginger extract. |
| Databáze: | OpenAIRE |
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