| Autor: |
G.G. Govan, P.R. Smith, H. Kellar-Wood, A.H.V. Schapira, A.E. Harding |
| Rok vydání: |
1994 |
| Předmět: |
|
| Zdroj: |
Journal of the neurological sciences. 126(2) |
| ISSN: |
0022-510X |
| Popis: |
There is an association between Leber's hereditary optic neuropathy (LHON) and a multiple sclerosis-like illness, raising the possibility of autoimmune pathogenetic mechanisms in LHON. We therefore investigated the frequency of HLA-DR genotypes in members of 79 families with LHON, defined by the presence of a pathogenic mitochondrial DNA mutation. There was no association between LHON and any HLA-DR genotype. Furthermore, affected relative pairs did not share HLA genotypes more than discordant pairs. We conclude that the HLA-DR locus is not a major genetic determinant for the development of blindness in LHON. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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