Physiological Responses in Humans Acutely Exposed to High Altitude (3480 m): Minute Ventilation and Oxygenation Are Predictive for the Development of Acute Mountain Sickness
| Autor: | Rudolf Likar, Martin Faulhaber, Martin Burtscher, Hannes Gatterer, Johannes Burtscher, Michael Philadelphy, Werner Nachbauer |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty ascent Physiology Blood Pressure Altitude Sickness 030204 cardiovascular system & hematology susceptibility Young Adult 03 medical and health sciences 0302 clinical medicine Diastole Heart Rate Internal medicine medicine Humans sex sexes cardiorespiratory response Aged hypoxia business.industry saturation association Public Health Environmental and Occupational Health Hypoxia (environmental) 030229 sport sciences General Medicine Oxygenation Middle Aged Effects of high altitude on humans Physiological responses Oxygen predictors gas-exchange age acute mountain sickness Cardiology Female heart-rate-variability Disease Susceptibility Pulmonary Ventilation business Respiratory minute volume |
| Zdroj: | High Altitude Medicine & Biology. 20:192-197 |
| ISSN: | 1557-8682 |
| DOI: | 10.1089/ham.2018.0143 |
| Popis: | Burtscher, Martin, Michael Philadelphy, Hannes Gatterer, Johannes Burtscher, Martin Faulhaber, Werner Nachbauer, and Rudolf Likar. Physiological responses in humans acutely exposed to high altitude (3480 m): Minute ventilation and oxygenation are predictive for the development of acute mountain sickness. High Alt Med Biol. 00:000-000, 2019.-The importance of arterial oxygen saturation for the prediction of acute mountain sickness (AMS) is still a matter of debate. Reasons for discrepancies may result from varying laboratory or field conditions and their interactions. Thus, we analyzed data from our prior high-altitude studies, including participants of a broad range of age of both sexes (20 males and 20 females, aged between 20 and 67 years) under strictly standardized conditions of pre-exposure and acute exposure to real high altitude (3480 m). A set of resting cardiovascular, respiratory, hematological, and metabolic variables were recorded at high altitude (Testa Grigia, Plateau Rosa, 3480 m; Swiss-Italian boarder) after performing pretests at low altitude (Innsbruck, 600 m, Austria). Our analyses indicate that (1) smaller changes in resting minute ventilation (VE) and a larger decrease of peripheral oxygen saturation (SpO(2)) during the first 3 hours of acute exposure to high altitude were independent predictors for subsequent development of AMS (90% correct prediction), (2) there are no differences of responses between sexes, and (3) there is no association of responses with age. Considering the independent effects of both responses (VE and SpO(2)) may be of clinical/practical relevance. Moreover, the presented data derived from a broad age range of both sexes might be of interest for comparative purposes. |
| Databáze: | OpenAIRE |
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