Electrochemical etching of micro-pores in medical grade cobalt–chromium alloy as reservoirs for drug eluting stents
| Autor: | Claus Burkhardt, Markus Herrmann, Kai Fuchsberger, Karoline Binder, Christian Freudigmann, Martin Stelzle |
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| Rok vydání: | 2016 |
| Předmět: |
Drug
Materials science media_common.quotation_subject medicine.medical_treatment Biomedical Engineering Biophysics Bioengineering 030204 cardiovascular system & hematology Prosthesis Design 030226 pharmacology & pharmacy Biomaterials 03 medical and health sciences 0302 clinical medicine Restenosis Materials Testing Coronary stent medicine Pitting corrosion media_common Sirolimus chemistry.chemical_classification Stent Drug-Eluting Stents Electrochemical Techniques Polymer medicine.disease Anti-Bacterial Agents Kinetics Nanopore chemistry Chromium Alloys Implant Biomedical engineering |
| Zdroj: | Journal of Materials Science: Materials in Medicine. 27 |
| ISSN: | 1573-4838 0957-4530 |
| Popis: | Drug eluting stents (DES) have shown efficacy in reducing restenosis after angioplasty followed by application of a coronary stent. However, polymer matrices typically used for immobilizing drugs on the stent surface may cause irritation and have limited drug loading capacity. In contrast, drug loading into micro- or nanopores created within the stent material could avoid these problems. We present a technology based on electrochemically induced pitting corrosion to form pores in medical grade steel, followed by loading with rapamycin. This process is applied to pore formation and drug loading in coronary stents consisting of L605 medical steel. Sustained release of the drug over 28 days at rates comparable to established DES was demonstrated. This technology is capable of creating pores with well-defined pore size and filling of these pores by a drug employing a crystallization process thus completely avoiding polymer matrices to immobilize drugs. Electrochemically induced pitting corrosion provides a generic means to introduce micro-pores suitable as drug reservoirs into medical grade steel without the need for any further matrix material. Further research will expand these findings to other materials and types of implants that could benefit from the additional function of drug release and/or improved implant/tissue integration. |
| Databáze: | OpenAIRE |
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