A Long Intergenic Non-coding RNA, LINC01426, Promotes Cancer Progression via AZGP1 and Predicts Poor Prognosis in Patients with LUAD
| Autor: | Guanzhen Li, Baorui Tian, Hua Jiang, Jianni Qi, Xiaoyang Han, Yingying Tian, Chuanxi Wang, Jiamei Li |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
lcsh:QH426-470 AZGP1 Biology LINC01426 medicine.disease_cause Article 03 medical and health sciences 0302 clinical medicine oncogene Genetics medicine lcsh:QH573-671 Molecular Biology Gene knockdown Oncogene lcsh:Cytology Cancer RNA lung adenocarcinoma Non-coding RNA medicine.disease hsa-miR-30b-3p lcsh:Genetics 030104 developmental biology 030220 oncology & carcinogenesis Cancer research Molecular Medicine Adenocarcinoma Carcinogenesis |
| Zdroj: | Molecular Therapy: Methods & Clinical Development, Vol 18, Iss, Pp 765-780 (2020) Molecular Therapy. Methods & Clinical Development |
| ISSN: | 2329-0501 |
| Popis: | Various long non-coding RNAs (lncRNAs) are closely associated with lung adenocarcinoma (LUAD), playing oncogenic or anti-oncogenic roles in tumorigenesis and progression. Herein, we report a novel lncRNA—long intergenic non-protein coding RNA 1426 (LINC01426)—that has not yet been characterized in LUAD. We note that LINC01426 expression was markedly upregulated in LUAD tissues, and that functional assays verified that LINC01426 knockdown markedly inhibited cell proliferation, migration, and invasion in vitro. Xenografts derived from A549 cells knocked down of LINC01426 had evidently lower tumor weights and smaller tumor volumes. Our study also found that LINC01426 bound to hsa-miR-30b-3p as a competitive endogenous RNA in LUAD. Moreover, LINC01426 affected LUAD wound healing by interacting and combining with AZGP1, and LINC01426 expression was significantly associated with tumor-node-metastasis (TNM) staging and prognosis in patients with LUAD. To summarize, our study elucidates the oncogenic roles of LINC01426 in LUAD tumorigenesis and progression. We think that LINC01426 can serve as a potential diagnostic biomarker and therapeutic target in patients with LUAD. Graphical Abstract LINC01426 was upregulated in LUAD tissues and could promote lung cancer cell progression. Moreover, LINC01426 was found to affect LUAD wound healing by interacting with AZGP1; additionally, LINC01426 bound to hsa-miR-30b-3p as a competitive endogenous RNA in LUAD. LINC01426 was associated with poor prognosis in patients with LUAD. |
| Databáze: | OpenAIRE |
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