New Context Significantly Changes Expression of Irs2 Gene in Hippocampal Areas

Autor: Anastasia M. Shvadchenko, Maria N. Volobueva, Violetta O. Ivanova, Alexandr P. Beletskiy, Gulnur R. Smirnova, Natalia V. Bal, Pavel M. Balaban
Rok vydání: 2022
Předmět:
Zdroj: Biochemistry (Moscow). 87:1243-1251
ISSN: 1608-3040
0006-2979
Popis: Memory formation is a complex process involving changes in the synaptic activity and gene expression encoding the insulin-like growth factors. We analyzed changes in the expression of genes encoding the insulin/insulin-like growth factors' proteins at the early period of learning in the CA1 region and dentate gyrus of the dorsal and ventral hippocampus in mice 1 hour after presentation of a new context (contextual fear conditioning) with and without negative reinforcement. It was found that in addition to changes in the expression of immediate early genes c-Fos (in all studied hippocampal fields) and Arc (in dorsal and ventral CA1, as well as in dorsal dentate gyrus), exposure to a new context significantly altered expression of the insulin receptor substrate 2 gene (Irs2) in dorsal CA1 and ventral dentate gyrus irrespectively of the negative reinforcement, which suggests participation of the insulin/IGF system in the early stages of neural activation during learning.
Databáze: OpenAIRE
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