Dopamine D2/D3-receptor and transporter densities in nucleus accumbens and amygdala of type 1 and 2 alcoholics
| Autor: | Erkki Tupala, Terttu Särkioja, Tuija Mantere, Jukka Hiltunen, Kim A. Bergström, Jari Tiihonen, Pirkko Räsänen, Håkan Hall, J. C. Callaway |
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| Rok vydání: | 2001 |
| Předmět: |
Adult
Male medicine.medical_specialty Pyrrolidines Nortropanes Dopamine Dopamine Plasma Membrane Transport Proteins Contrast Media Nerve Tissue Proteins Nucleus accumbens Amygdala Nucleus Accumbens Iodine Radioisotopes Radioligand Assay Cellular and Molecular Neuroscience chemistry.chemical_compound Dopamine receptor D3 Internal medicine medicine Humans Neurotransmitter Receptor Molecular Biology Membrane Glycoproteins Receptors Dopamine D2 Chemistry Dopaminergic Receptors Dopamine D3 Membrane Transport Proteins Alcoholism Psychiatry and Mental health Endocrinology medicine.anatomical_structure Benzamides Female Carrier Proteins Neuroscience medicine.drug |
| Zdroj: | Molecular Psychiatry. 6:261-267 |
| ISSN: | 1476-5578 1359-4184 |
| Popis: | Alcohol acts through mechanisms involving the brain neurotransmitter dopamine (DA) with the nucleus accumbens as the key zone for mediating these effects. We evaluated the densities of DA D(2)/D(3) receptors and transporters in the nucleus accumbens and amygdala of post-mortem human brains by using [(125)l]epidepride and [(125)I]PE2I as radioligands in whole hemispheric autoradiography of Cloninger type 1 and 2 alcoholics and healthy controls. When compared with controls, the mean binding of [(125)I]epidepride to DA D(2)/D(3) receptors was 20% lower in the nucleus accumbens and 41% lower in the amygdala, and [(125)I]PE2I binding to DA transporters in the nucleus accumbens was 39% lower in type 1 alcoholics. These data indicate that dopaminergic functions in these limbic areas may be impaired among type 1 alcoholics, due to the substantially lower number of receptor sites. Our results suggest that such a reduction may result in the chronic overuse of alcohol as an attempt to stimulate DA function. |
| Databáze: | OpenAIRE |
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