Handgrip Strength Is an Independent Predictor of Cardiovascular Outcomes in Diabetes Mellitus
| Autor: | Manabu Horii, Yuta Yamamoto, Yoshinobu Morikawa, Rika Kawakami, Matahiro Yabuta, Yoshihiko Saito |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Sarcopenia medicine.medical_specialty 030204 cardiovascular system & hematology Independent predictor Diabetes Complications 03 medical and health sciences 0302 clinical medicine Japan Diabetes mellitus Internal medicine Clinical endpoint medicine Humans 030212 general & internal medicine Aged Hand Strength business.industry Incidence (epidemiology) Hazard ratio General Medicine Middle Aged medicine.disease Cardiovascular Diseases Female Cardiology and Cardiovascular Medicine business human activities Cardiovascular outcomes Mace Follow-Up Studies |
| Zdroj: | International Heart Journal. 62:50-56 |
| ISSN: | 1349-3299 1349-2365 |
| DOI: | 10.1536/ihj.20-677 |
| Popis: | Diabetes mellitus (DM) is associated with an increased incidence of cardiovascular events and an elevated prevalence of sarcopenia. However, the relationship between cardiovascular events and sarcopenia in patients with DM remains unclear. This study examined this relationship and investigated the predictors of cardiovascular events in this population.This study enrolled 161 patients with DM and no history of cardiovascular diseases who were admitted to our hospital for the treatment of DM between September 2012 and December 2015. Patients were divided into sarcopenia and non-sarcopenia groups, and were followed until March 2019. The primary endpoint was major adverse cardiovascular events (MACE).The mean age was 65.9 ± 1.8 years old and the mean follow-up period was 4.1 ± 0.8 years. The log-rank test indicated that MACE differed significantly between the two groups (P < 0.0001). Multivariate Cox hazard analysis identified the cardio-ankle vascular index (CAVI) and handgrip strength as independent predictors of MACE (hazard ratio [HR] = 1.18, P = 0.039; and HR = 0.70, P = 0.016, respectively).Handgrip strength is an indicator of sarcopenia in diabetic patients, and together with CAVI it was independently associated with the incidence of MACE. This suggests that the handgrip strength test might be useful in the management of patients with DM at high risk of cardiovascular outcomes. |
| Databáze: | OpenAIRE |
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