Precision of Discrete and Rhythmic Forelimb Movements Requires a Distinct Neuronal Subpopulation in the Interposed Anterior Nucleus
| Autor: | Alaric K. K. Yip, Jinsook Kim, Albert I. Chen, Kelly L. L. Wong, George J. Augustine, Martesa Tantra, Ayesha R. Thanawalla, Aloysius Y. T. Low |
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| Přispěvatelé: | Interdisciplinary Graduate School (IGS), Lee Kong Chian School of Medicine (LKCMedicine), School of Biological Sciences |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cerebellum Light Movement Population Optogenetics Biology Deep cerebellar nuclei General Biochemistry Genetics and Molecular Biology Cerebellar Cortex 03 medical and health sciences Glutamatergic 0302 clinical medicine Glutamates Forelimb medicine Animals education lcsh:QH301-705.5 Neurons education.field_of_study DCN IntA Mice Inbred C57BL 030104 developmental biology medicine.anatomical_structure lcsh:Biology (General) Cerebellar Nuclei nervous system Cerebellar cortex Gene Targeting Nerve Net Neuroscience Nucleus Locomotion 030217 neurology & neurosurgery |
| Zdroj: | Cell Reports, Vol 22, Iss 9, Pp 2322-2333 (2018) |
| Popis: | Summary: The deep cerebellar nuclei (DCN) represent output channels of the cerebellum, and they transmit integrated sensorimotor signals to modulate limb movements. But the functional relevance of identifiable neuronal subpopulations within the DCN remains unclear. Here, we examine a genetically tractable population of neurons in the mouse interposed anterior nucleus (IntA). We show that these neurons represent a subset of glutamatergic neurons in the IntA and constitute a specific element of an internal feedback circuit within the cerebellar cortex and cerebello-thalamo-cortical pathway associated with limb control. Ablation and optogenetic stimulation of these neurons disrupt efficacy of skilled reach and locomotor movement and reveal that they control positioning and timing of the forelimb and hindlimb. Together, our findings uncover the function of a distinct neuronal subpopulation in the deep cerebellum and delineate the anatomical substrates and kinematic parameters through which it modulates precision of discrete and rhythmic limb movements. : The deep cerebellar nuclei transmit integrated sensorimotor signals to modify movement. Using a urocortin 3::Cre mouse line, Low et al. identify a subpopulation of glutamatergic neurons in the interposed anterior nucleus required for specific kinematic parameters of rhythmic and discrete movement via connectivity with forelimb-associated nucleocortical and nucleofugal pathways. Keywords: cerebellum, deep cerebellar nuclei, DCN, interposed anterior nucleus, IntA, skilled reach, locomotion, urocortin 3, Ucn3, efference copy |
| Databáze: | OpenAIRE |
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