Comparison of T cell responses in patients with a long-term surviving renal allograft versus a long-term surviving liver allograft. It's a different world
| Autor: | M. J. H. Slooff, S. P. M. Lems, J. de Hoop, J. M. Wilmink, R.J.M. ten Berge, L. P. de Waal, A. P. Van De Berg, E. van Twuyver |
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| Přispěvatelé: | Other departments |
| Jazyk: | angličtina |
| Rok vydání: | 1996 |
| Předmět: |
Cytotoxicity
Immunologic Cellular immunity Time Factors T-Lymphocytes T cell medicine.medical_treatment Liver transplantation Lymphocyte Activation medicine Humans Cytotoxic T cell Kidney transplantation Immunity Cellular Transplantation Kidney business.industry Graft Survival medicine.disease Kidney Transplantation Liver Transplantation medicine.anatomical_structure surgical procedures operative Histocompatibility Immunology Lymphocyte Culture Test Mixed business Allotransplantation |
| Zdroj: | Transplantation, 61(9), 1392-1397. Lippincott Williams and Wilkins |
| ISSN: | 0041-1337 |
| Popis: | The aim of the present study was to analyze whether acquired transplantation tolerance had developed in patients with a long-term surviving renal or liver allograft. Analysis of antidonor cytotoxic T cell precursor frequencies was performed in 31 renal allograft recipients and 9 liver allograft recipients with good graft function 2 years after transplantation. The results demonstrated that, before transplantation, normal antidonor T cell responses were generated in both groups of patients. Two years after transplantation, donor-specific CTL nonresponsiveness had developed in a minority of the renal transplant recipients. In contrast, 8 out of 9 liver transplant recipients showed donor-specific mixed lymphocyte culture and CTL nonresponsiveness. These findings indicate that development of donor-specific T cell nonresponsiveness is not a common event after kidney transplantation, whereas liver transplantation seems to induce, at least in vitro, a state of donor-specific T cell nonresponsiveness. |
| Databáze: | OpenAIRE |
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