Combined Effects of Exercise and Phytoanabolic Extracts in Castrated Male and Female Mice
| Autor: | Maria M. Campos, Jarbas Rodrigues de Oliveira, Rodrigo B. M. Silva, Matheus S Nunes, J P Martins, Lucia C Silva, Gabriel Rübensam |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Male Sarcopenia Eurycoma longifolia Anabolism chemistry.chemical_compound Mice 0302 clinical medicine Anabolic Agents Weight loss ergogenic phytotherapics Orchiectomy Eurycoma Urtica dioica Adiposity Nutrition and Dietetics biology medicine.anatomical_structure 030220 oncology & carcinogenesis Female medicine.symptom lcsh:Nutrition. Foods and food supply medicine.medical_specialty Ovariectomy lcsh:TX341-641 Ajuga Article 03 medical and health sciences Magnoliopsida Internal medicine Ajuga turkestanica Physical Conditioning Animal medicine Animals Muscle Skeletal Cholesterol business.industry Plant Extracts aging Skeletal muscle medicine.disease biology.organism_classification Disease Models Animal 030104 developmental biology Endocrinology resistance exercise chemistry Dietary Supplements business Food Science |
| Zdroj: | Nutrients, Vol 13, Iss 1177, p 1177 (2021) Nutrients Volume 13 Issue 4 |
| ISSN: | 2072-6643 |
| Popis: | Dry extracts from the Eurasian plants, Ajuga turkestanica, Eurycoma longifolia, and Urtica dioica have been used as anabolic supplements, despite the limited scientific data on these effects. To assess their actions on early sarcopenia signs, male and female castrated mice were supplemented with lyophilized extracts of the three plants, isolated or in association (named TLU), and submitted to resistance exercise. Ovariectomy (OVX) led to body weight increase and non-high-density cholesterol (HDL) cholesterol elevation, which had been restored by exercise plus U. dioica extract, or by exercise and TLU, respectively. Orchiectomy (ORX) caused skeletal muscle weight loss, accompanied by increased adiposity, being the latter parameter reduced by exercise plus E. longifolia or U. dioica extracts. General physical activity was improved by exercise plus herbal extracts in either OVX or ORX animals. Exercise combined with TLU improved resistance to fatigue in OVX animals, though A. turkestanica enhanced the grip strength in ORX mice. E. longifolia or TLU also reduced the ladder climbing time in ORX mice. Resistance exercise plus herbal extracts partly altered gastrocnemius fiber size frequencies in OVX or ORX mice. We provide novel data that tested ergogenic extracts, when combined with resistance exercise, improved early sarcopenia alterations in castrated male and female mice. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|