Polyomavirus-associated Prostatitis in Wistar Han Rats Following Immunosuppression in a Chronic Toxicity Study
| Autor: | Katherine Masek-Hammerman, Marie Debrue, Laurence O. Whiteley, Zaher A. Radi, Lindsay Tomlinson, Thomas P. Brown, Walter F. Bobrowski |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Male Pathology medicine.medical_specialty 040301 veterinary sciences medicine.medical_treatment Cell Prostatitis Inflammation Biology Toxicology Pathology and Forensic Medicine 0403 veterinary science 03 medical and health sciences Immune system Prostate medicine Animals Immunologic Factors Rats Wistar Toxicity Tests Chronic Molecular Biology Chronic toxicity Immunosuppression Therapy Polyomavirus Infections Immunosuppression 04 agricultural and veterinary sciences Cell Biology medicine.disease Epithelium Rats Tumor Virus Infections 030104 developmental biology medicine.anatomical_structure medicine.symptom Polyomavirus |
| Zdroj: | Toxicologic pathology. 45(5) |
| ISSN: | 1533-1601 |
| Popis: | Chronic prostatitis characterized on light microscopic examination by moderate, multifocal, predominantly lymphocytic inflammation associated with epithelial atypia and intranuclear and cytoplasmic inclusion-like material was identified in the prostate gland of 2 Wistar Han rats administered an immunomodulatory test article in a 6-month chronic toxicity study. Transmission electron microscopy of the prostate glands identified 45-nm, nonenveloped, icosahedral virions arranged in paracrystalline array within the cell nuclei in 1 of the 2 rats. The size, shape, location, and array pattern were most consistent with a polyomavirus. The light and electron microscopic findings after immunosuppression in our case have a resemblance to a polyomavirus recently reported to affect prostate gland epithelium in a colony of immunocompromised X-linked severe combined immune deficiency rats. To the best of our knowledge, this is the first report of light and electronic microscopic lesions in the reproductive tract associated with polyomavirus following chronic immunosuppression in a widely used, wild-type Wistar Han rat. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|