Effectiveness of palonosetron for preventing delayed chemotherapy-induced nausea and vomiting following moderately emetogenic chemotherapy in patients with gastrointestinal cancer
| Autor: | Takeshi Siraishi, Kyohei Yamaguchi, Shozo Senba, Ikuko Yamaguchi, Michiyasu Murakami, Hiroki Hashimoto |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Quinuclidines medicine.medical_specialty Vomiting medicine.drug_class Nausea Antineoplastic Agents Granisetron Gastroenterology Surveys and Questionnaires Internal medicine medicine Humans Antiemetic Prospective Studies Gastrointestinal cancer Aged Gastrointestinal Neoplasms Aged 80 and over business.industry Palonosetron Common Terminology Criteria for Adverse Events Middle Aged Isoquinolines medicine.disease Oncology Anesthesia Antiemetics Female medicine.symptom business medicine.drug Chemotherapy-induced nausea and vomiting |
| Zdroj: | Supportive Care in Cancer. 22:905-909 |
| ISSN: | 1433-7339 0941-4355 |
| Popis: | Patients with gastrointestinal cancer who were receiving moderately emetogenic chemotherapy (MEC) were switched from granisetron, a first-generation 5-hydroxytryptamine-3 receptor antagonist, to palonosetron at our hospital. In the present study, we compared effectiveness before and after switching antiemetic treatment. Among patients who were receiving MEC for gastrointestinal cancer, we prospectively observed 46 patients given granisetron and 46 given palonosetron. To allow adverse reactions to be graded in accordance with the Common Terminology Criteria for Adverse Events, version 4.0, a questionnaire designed at our hospital was used to compare the occurrence of delayed nausea and vomiting between patients who received granisetron (GRA group) and those who received palonosetron (PAL group). The incidence of delayed nausea was significantly lower in the PAL group (8.7 %, 4/46; p |
| Databáze: | OpenAIRE |
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