Serum Clara cell 16-kDa protein levels and lung impairment in systemic sclerosis patients
| Autor: | Dorota Trzybulska, Halina Batura-Gabryel, Paweł Hrycaj, Katarzyna Katulska, Anna Olewicz-Gawlik, Aleksandra Dańczak-Pazdrowska, Barbara Kuznar-Kaminska |
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| Rok vydání: | 2016 |
| Předmět: |
Pathology
medicine.medical_specialty High-resolution computed tomography Doença intersticial pulmonar lcsh:Diseases of the musculoskeletal system Enzyme-Linked Immunosorbent Assay Interstitial lung disease Disease 03 medical and health sciences 0302 clinical medicine Diffusing capacity Esclerose sistêmica medicine Humans Plethysmograph Lung volumes Lung Plethysmography Whole Body General Environmental Science 030203 arthritis & rheumatology Scleroderma Systemic medicine.diagnostic_test business.industry Blood Proteins respiratory system medicine.disease respiratory tract diseases medicine.anatomical_structure 030228 respiratory system Case-Control Studies Clara cell Systemic sclerosis General Earth and Planetary Sciences lcsh:RC925-935 Lung Diseases Interstitial business Biomarkers CC16 |
| Zdroj: | Revista Brasileira de Reumatologia, Vol 56, Iss 4, Pp 309-313 Revista Brasileira de Reumatologia v.56 n.4 2016 Revista Brasileira de Reumatologia Sociedade Brasileira de Reumatologia (SBR) instacron:SBR |
| ISSN: | 2255-5021 |
| Popis: | Objective: To assess clinical utility of serum Clara cell 16-kDa protein measurements in relation with staging system for systemic sclerosis associated interstitial lung disease. Materials and methods: Serum levels of Clara cell 16-kDa protein were determined by ELISA in 28 systemic sclerosis patients and 30 healthy controls, and correlated with staging system for systemic sclerosis associated interstitial lung disease in systemic sclerosis patients. Lung involvement was assessed functionally (body plethysmography, diffusing capacity of the lung for carbon monoxide) and radiologically (an average disease extent on high resolution computed tomography of the lungs) in SSc patients. Results: We observed statistically significant differences in serum Clara cell 16-kDa protein levels between systemic sclerosis patients and healthy controls only in non-smokers. However, serum Clara cell 16-kDa protein concentrations were significantly elevated in patients with high resolution computed tomography extent >20% in comparison to patients with high resolution computed tomography extent |
| Databáze: | OpenAIRE |
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