Biocompatibility of a Polymeric Implant for the Treatment of Osteomyelitis
| Autor: | Boaz Mizrahi, Abraham J. Domb, Yaron S. Brin, Jacob Golenser, M Nyska, Abraham Nyska |
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| Rok vydání: | 2009 |
| Předmět: |
Male
medicine.medical_specialty Materials science Biocompatibility Polymers medicine.drug_class Antibiotics Biomedical Engineering Biophysics Bioengineering Pharmacology Injections Biomaterials Fibrosis Materials Testing medicine Animals Rats Wistar Inflammation Drug Carriers Osteomyelitis Bacterial Infections medicine.disease Controlled release Anti-Bacterial Agents Rats Surgery Gentamicin Sulfate Delayed-Action Preparations Gentamicin Implant medicine.drug |
| Zdroj: | Journal of Biomaterials Science, Polymer Edition. 20:1081-1090 |
| ISSN: | 1568-5624 0920-5063 |
| DOI: | 10.1163/156856209x444439 |
| Popis: | We evaluated the biocompatibility of an injectable gelling polymeric device for the controlled release of gentamicin sulfate in the treatment of invasive bacterial infections in bone of male Wister rats. The biodegradable delivery carrier, poly(sebacic-co-ricinoleic-ester-anhydride), designated as p(SA:RA), was injected, with and without gentamicin, into the tibial canal. Rats were killed 3 weeks later. The tibiae were processed histologically, leaving the injectable polymer in situ. The local tissue reaction to the polymer with or without antibiotic consisted mainly of mild reactive fibroplasia/fibrosis and mild to moderate increased reactive bone formation. At this stage, no evidence for any active inflammatory response to the polymer was seen. Thus, the injection of p(SA:RA) was well tolerated and did not induce any signs of a progressive inflammatory reaction. |
| Databáze: | OpenAIRE |
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