E-Cadherin Gene 3′-UTR C/T Polymorphism Is Associated with Prostate Cancer
| Autor: | Ming Tsung Lai, Lei Wan, Fuu Jen Tsai, Wen Chi Chen, Hsi Chin Wu, Huey Yi Chen, Chao I. Wu |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Male
Genotype Urology Biology Polymerase Chain Reaction Prostate cancer Extracellular medicine Humans Allele Gene Alleles Aged Neoplasm Staging Aged 80 and over Polymorphism Genetic Cadherin Three prime untranslated region Biopsy Needle Prostatic Neoplasms DNA Neoplasm Middle Aged Cadherins medicine.disease Molecular biology Disease Progression Intracellular Follow-Up Studies |
| Zdroj: | Urologia Internationalis. 75:350-353 |
| ISSN: | 1423-0399 0042-1138 |
| Popis: | Introduction: E-cadherin (CDH-1) is a cell-cell adhesive molecule which maintains cell integrity and communication between the intracellular and extracellular world. CDH-1 may therefore be related to carcinogenesis. A polymorphism located at the 3′-UTR of the CDH-1 gene is associated with stone disease; however, its relationship to prostate cancer has not been reported. We aimed to study whether there is an association between the 3′-UTR polymorphism and prostate cancer. Materials and Methods: We collected 96 patients with prostate cancer and 114 normal controls for this study. The polymorphism of the CDH-1 gene was studied by polymerase chain reaction-based restriction analysis. Results:There was a significant difference in genotype distribution of the CDH-1 gene polymorphism between cancer patients and normal controls (p < 0.001). The distribution of the CDH-1 gene CC genotype in prostate cancer patients (51.0%) was higher than in the controls (10.5%). The odds ratio for the CDH-1 ‘C’ allele was 2.896 (95% CI = 1.908–4.396). There was no significant difference according to age, pathological grading, clinical staging, and responsiveness to hormonal therapy among patients. Only 3 patients (3.1%) had a history of urolithiasis. Conclusions:The CDH-1 gene 3′-UTR C/T polymorphism is associated with prostate cancer. The ‘CC’ homozygote indicates a relatively higher risk for developing prostate cancer than other genotypes. |
| Databáze: | OpenAIRE |
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