A complex mTOR response in habituation paradigms for a social signal in adult songbirds
| Autor: | Elisa O. Gores, Sarah E. London, Somayeh Ahmadiantehrani |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Auditory Pathways Cognitive Neuroscience Avian Proteins 03 medical and health sciences Cellular and Molecular Neuroscience Prosencephalon 0302 clinical medicine Animals Enzyme Inhibitors Habituation Habituation Psychophysiologic Mechanistic target of rapamycin PI3K/AKT/mTOR pathway Sirolimus Molecular signaling biology Mechanism (biology) TOR Serine-Threonine Kinases Research Recognition Psychology Cognition Associative learning 030104 developmental biology Neuropsychology and Physiological Psychology Pattern Recognition Physiological Neural processing Auditory Perception biology.protein Female Finches Vocalization Animal Psychology Neuroscience 030217 neurology & neurosurgery Signal Transduction |
| Zdroj: | Learning & Memory. 25:273-282 |
| ISSN: | 1549-5485 |
| DOI: | 10.1101/lm.046417.117 |
| Popis: | Nonassociative learning is considered simple because it depends on presentation of a single stimulus, but it likely reflects complex molecular signaling. To advance understanding of the molecular mechanisms of one form of nonassociative learning, habituation, for ethologically relevant signals we examined song recognition learning in adult zebra finches. These colonial songbirds learn the unique song of individuals, which helps establish and maintain mate and other social bonds, and informs appropriate behavioral interactions with specific birds. We leveraged prior work demonstrating behavioral habituation for individual songs, and extended the molecular framework correlated with this behavior by investigating the mechanistic Target of Rapamycin (mTOR) signaling cascade. We hypothesized that mTOR may contribute to habituation because it integrates a variety of upstream signals and enhances associative learning, and it crosstalks with another cascade previously associated with habituation, ERK/ZENK. To begin probing for a possible role for mTOR in song recognition learning, we used a combination of song playback paradigms and bidirectional dysregulation of mTORC1 activation. We found that mTOR demonstrates the molecular signatures of a habituation mechanism, and that its manipulation reveals the complexity of processes that may be invoked during nonassociative learning. These results thus expand the molecular targets for habituation studies and raise new questions about neural processing of complex natural signals. |
| Databáze: | OpenAIRE |
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