No Major Effect of Orciprenaline and Propranolol upon ACTH-Induced Cortisol Secretion
| Autor: | A Nonell, Daniel Kopf, Michael Deuschle, Florian Lederbogen, S Lewicka, S Kerk, B Hamann |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Cortisol secretion endocrine system medicine.medical_specialty Hydrocortisone Endocrinology Diabetes and Metabolism Adrenergic beta-Antagonists Pituitary-Adrenal System Dehydroepiandrosterone Propranolol Adrenocorticotropic hormone Orciprenaline Endocrinology Adrenocorticotropic Hormone Internal medicine Receptors Adrenergic beta Internal Medicine medicine Humans Secretion business.industry General Medicine Adrenergic beta-Agonists Metaproterenol Cosyntropin Secretory Rate business hormones hormone substitutes and hormone antagonists Glucocorticoid medicine.drug |
| Zdroj: | Experimental and Clinical Endocrinology & Diabetes. 112:59-61 |
| ISSN: | 1439-3646 0947-7349 |
| DOI: | 10.1055/s-2004-815721 |
| Popis: | Preclinical research suggests adrenal beta-adrenergic receptors to be involved in the regulation of steroid synthesis. In a group of healthy male volunteers, we compared ACTH-induced cortisol and dehydroepiandrosterone (DHEA) secretion after pre-treatment with orciprenaline, propranolol or placebo. Neither baseline nor ACTH-induced steroid secretion differed between these conditions. Our data do not support the hypothesis that the adrenal beta-receptor plays a major role in steroid secretion in humans. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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