Efficacy and safety of a new microneedle patch for skin brightening: A Randomized, split-face, single-blind study
| Autor: | Jun Jin Yoon, Daegun Kim, Changjin Lee, Kui Young Park, Beom Joon Kim, Myeong Nam Kim, Hyun Jung Kwon |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
medicine.medical_specialty Skin Lightening Preparations Transdermal Patch Skin Pigmentation Cosmetic Techniques 02 engineering and technology Dermatology medicine.disease_cause 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Dermal Fillers medicine Single-Blind Study Humans Single-Blind Method Hyaluronic Acid Transdermal business.industry Skin whitening Middle Aged 021001 nanoscience & nanotechnology Skin Aging Skin irritation Needles Female Irritation 0210 nano-technology business |
| Zdroj: | Journal of Cosmetic Dermatology. 16:382-387 |
| ISSN: | 1473-2130 |
| Popis: | SummaryBackground Although microneedles are one of the best transdermal drug delivery systems for active compounds, few clinical trials have examined the safety and efficacy of brightening microneedle patches. Aims To determine the efficacy and safety of a newly developed whitening microneedle patch. Patients/Methods A split-face study was designed for efficacy assessment with 34 Korean women applying the tested product (a whitening microneedle patch) on one cheek and a control whitening essence on the other. We objectively measured changes in melanin index values and skin brightness by mexameter and chromameter. Each participant also used global assessment to determine skin whitening. In addition, 55 participants were selected for primary skin irritation tests and repeated insult patch tests for safety assessments. Results Mean skin brightness and melanin indexes improved (P |
| Databáze: | OpenAIRE |
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