Evaluation of cerebrospinal fluid CXCL13 concentrations and lymphocyte subsets in tick-borne encephalitis
| Autor: | Artur Sulik, Joanna Osada, Sambor Grygorczuk, Marta Wozinska-Klepadlo, Kacper Toczylowski, Małgorzata Wojtkowska, Paulina Potocka, Ewa Bojkiewicz |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Adult Male Adolescent 030106 microbiology Population Antibodies Viral lcsh:Infectious and parasitic diseases Encephalitis Viruses Tick-Borne 03 medical and health sciences Young Adult 0302 clinical medicine Cerebrospinal fluid Meningoencephalitis medicine Humans lcsh:RC109-216 030212 general & internal medicine Lymphocyte Count CXCL13 education Child Cerebrospinal Fluid education.field_of_study B-Lymphocytes biology business.industry Tick-borne encephalitis General Medicine Middle Aged medicine.disease Chemokine CXCL13 Lymphocyte Subsets Killer Cells Natural Infectious Diseases Child Preschool Immunology biology.protein Female Antibody business Meningitis Encephalitis Encephalitis Tick-Borne |
| Zdroj: | International Journal of Infectious Diseases, Vol 93, Iss, Pp 40-47 (2020) |
| ISSN: | 1878-3511 |
| Popis: | Objectives: Recent studies suggest that the clinical presentation of tick-borne encephalitis (TBE) is determined by the host immune responses to the tick-borne encephalitis virus (TBEV). The aim of the study was to characterize immune responses in TBE to give a better insight into the immunopathogenesis of this disease. Methods: Anti-TBEV antibody levels, cerebrospinal fluid (CSF) and blood lymphoid populations, and concentrations of CXCL13 (a potent B-cell and T-cell chemoattractant), were analyzed in 35 patients with TBE (20 adults and 15 children). Results: When compared with the blood, the CSF lymphoid population was significantly enriched in CD4+ T-cells and relatively depleted in natural killer (NK) cells and B lymphocytes. In comparison with TBE meningitis, patients suffering from TBE meningoencephalitis (n = 11, 31%) had a 3.5-fold higher median CSF CXCL13 concentration, 1.8-fold higher CSF/serum ratio of anti-TBEV IgG antibodies, and 1.8-fold higher median CSF cell count. CSF CXCL13 levels did not change significantly in children with TBE meningitis receiving supportive treatment, but decreased in children with TBE meningoencephalitis who received intravenous steroids. Conclusions: CD4+ cells are abundant in the CSF of patients with TBE. CXCL13 may be involved in the neuropathology of TBE by attracting different subsets of lymphocytes to the CSF. Keywords: Tick-borne encephalitis, Meningitis, CXCL13, Flow cytometry |
| Databáze: | OpenAIRE |
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